MELK and ZNF622

Number of citations of the paper that reports this interaction (PMID 11802789)
14

Data Source:
HPRD (two hybrid, in vivo)

		MELK	ZNF622
Gene Name		maternal embryonic leucine zipper kinase	zinc finger protein 622
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell Cortex Membrane	Nucleolus Cytoplasm Golgi Apparatus
	Molecular Function	Protein Serine/threonine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding	Protein Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Kinase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CDC25B CDC5L EIF2S1 HIST1H1B LMNB1 MBP PPP1R8 SF3B1 ZNF622	3 interactors: APP MELK MYBL2
Entrez ID		9833	90441
HPRD ID		06119	12278
Ensembl ID		ENSG00000165304	ENSG00000173545
Uniprot IDs		B7Z1G6 Q14680	Q969S3
PDB IDs		4BKY 4BKZ 4BL1 4IXP
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing Positive Regulation Of Kinase Activity MRNA Metabolic Process Positive Regulation Of Transferase Activity RNA Processing Defense Response To Nematode	G2/M Transition Of Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Response To Oxidative Stress Neuron Remodeling Cellular Copper Ion Homeostasis Mitotic Cell Cycle Process Mitotic Spindle Assembly Copper Ion Homeostasis Suckling Behavior Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Microtubule-based Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cell Cycle RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Mitotic Spindle Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death
Tagcloud ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Difference) ?		axis caenorhabditis catalytic coexpressed collectively contributes driven elegans evolutionarily ezh2 foxm1 gbm glioblastoma gsc gscs inversely irradiation mitotic oncogenic phosphorylates polycomb possibility postirradiation radioresistance raise repressive serve tumorigenic turn
Tagcloud (Intersection) ?