MELK and ZNF622

Number of citations of the paper that reports this interaction (PubMedID 11802789)
30

Data Source:
HPRD (two hybrid, in vivo)

		MELK	ZNF622
Description		maternal embryonic leucine zipper kinase	zinc finger protein 622
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Cortex Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Preribosome, Large Subunit Precursor
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Preribosome Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Apoptotic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Hemopoiesis Positive Regulation Of Apoptotic Process Protein Autophosphorylation Neural Precursor Cell Proliferation	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Kinase Activity Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade
Pathways
Drugs		Fostamatinib
Diseases
GWAS			Attention function in attention deficit hyperactive disorder ( 26174813)
Interacting Genes		11 interacting genes: CDC25B CDC5L EIF2S1 EZH2 H1-5 LMNB1 MAPT MBP PPP1R8 SF3B1 ZNF622	9 interacting genes: APP BEND7 CDC42 HMGB2 MACROH2A1 MELK MYBL2 OGT PRKN
Entrez ID		9833	90441
HPRD ID		06119	12278
Ensembl ID		ENSG00000165304	ENSG00000173545
Uniprot IDs		B7Z1G6 Q14680	Q969S3
PDB IDs		4BKY 4BKZ 4BL1 4D2P 4D2T 4D2V 4D2W 4IXP 4UMP 4UMQ 4UMR 4UMT 4UMU 5IH8 5IH9 5IHA 5IHC 5K00 5M5A 5MAF 5MAG 5MAH 5MAI 5TVT 5TWL 5TWU 5TWY 5TWZ 5TX3 6GVX 6VXR 9F31	6LQM 6LSR 9GMO
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus Nuclear Periphery Double-stranded DNA Binding Spliceosomal Complex Nucleoplasm Stress Granule Assembly Translation Initiation Ternary Complex Cellular Response To Chemical Stress Cellular Response To Heat Cellular Response To Oxidative Stress Hepatocyte Homeostasis Chromatin Remodeling Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Positive Regulation Of Metalloendopeptidase Activity Ribonuclease E Activity U11/U12 SnRNP Positive Regulation Of Catalytic Activity RNA Splicing Catalytic Step 2 Spliceosome Response To Heat Response To Oxidative Stress Chromatin DNA Binding Cellular Response To Trichostatin A Chromatin Organization Structural Constituent Of Nuclear Lamina Neurofibrillary Tangle Assembly Nuclear Speck Regulation Of Gene Expression MRNA Processing Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot Response To Kainic Acid Eukaryotic Translation Initiation Factor 2 Complex Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Hydrolase Activity Cellular Response To Reactive Oxygen Species Histone H3K27 Trimethyltransferase Activity Response To Tetrachloromethane Regulation Of Metallopeptidase Activity Internode Region Of Axon Compact Myelin Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translational Initiation In Response To Stress	Regulation Of Purine Nucleotide Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Regulation Of ATP Metabolic Process Cellular Response To Manganese Ion RAGE Receptor Binding Regulation Of Small Molecule Metabolic Process Protein-containing Complex Response To Manganese Ion Cellular Component Assembly Cellular Response To Catecholamine Stimulus Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Neurotransmitter Uptake Response To Catecholamine Negative Regulation Of Transcription By RNA Polymerase II Hemopoiesis Amyloid Fibril Formation Regulation Of Response To Oxidative Stress Positive Regulation Of Proteolysis Regulation Of Phosphorus Metabolic Process Negative Regulation Of Gene Expression Chemoattractant Activity Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Metabolic Process Negative Regulation Of Protein Localization Condensed Chromosome Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Gene Expression Postsynapse Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Chemotaxis Positive Regulation Of Developmental Process Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Gene Expression, Epigenetic Protein-containing Complex Organization Regulation Of Glycolytic Process Negative Regulation Of RNA Metabolic Process Mitophagy Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Synapse Organization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Amylin Binding Regulation Of Transcription By RNA Polymerase II
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