PRKD2 and HEY1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		PRKD2	HEY1
Description		protein kinase D2	hes related family bHLH transcription factor with YRPW motif 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Adaptive Immune Response Immune System Process Protein Phosphorylation Cell Adhesion Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Sphingolipid Biosynthetic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-8 Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Endothelial Tube Morphogenesis Regulation Of T Cell Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Negative Regulation Of Biomineral Tissue Development Circulatory System Development Regulation Of Vasculogenesis
Pathways		Sphingolipid de novo biosynthesis	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Post bronchodilator FEV1 ( 26634245) Primary sclerosing cholangitis ( 23603763 27992413)	Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)
Interacting Genes		17 interacting genes: CASK DST GORASP1 GRIP1 HDAC7 HEY1 IFNAR1 MTF2 PDLIM7 PFDN1 PSG3 RARB RRBP1 RXRA SNRNP70 TGOLN2 VPS26C	22 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HUNK KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 OLIG2 PITX2 PLEKHB2 PRKD2 SKIL SMAD3 SMAD9 TENT5D TP53 YTHDF1
Entrez ID		25865	23462
HPRD ID		09523	04260
Ensembl ID		ENSG00000105287	ENSG00000164683
Uniprot IDs		Q9BZL6	B4DEI9 Q9Y5J3
PDB IDs		2COA 3BGM 4NNX 4NNY	2DB7
Enriched GO Terms of Interacting Partners?			Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Lens Fiber Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Developmental Process Regulation Of Cell Population Proliferation Cellular Response To Actinomycin D Chromatin DNA Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BHLH Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Metabolic Process Response To Actinomycin D Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Antibiotic Cellular Response To UV-C Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression
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