FNTB and TLX3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FNTB	TLX3
Description		farnesyltransferase, CAAX box, subunit beta	T cell leukemia homeobox 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Catalytic Activity Prenyltransferase Activity Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding Protein Prenyltransferase Activity Acetyltransferase Activator Activity Transferase Activity Enzyme Binding Peptide Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Positive Regulation Of Cell Population Proliferation Protein Farnesylation Positive Regulation Of Cell Cycle Regulation Of Microtubule-based Movement	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Neuron Differentiation Negative Regulation Of Neuron Differentiation Animal Organ Development Neuron Fate Specification GABAergic Neuron Differentiation
Pathways		Inactivation, recovery and regulation of the phototransduction cascade RAS processing Potential therapeutics for SARS
Drugs		AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Blood trace element (Zn levels) ( 23720494) Eosinophil count ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 32888494 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252 29403010) Mean corpuscular volume ( 19862010 32888494 28017375 27863252) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494) Red blood cell count ( 27863252 32888494) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Body size at age 10 ( 32376654)
Interacting Genes		17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRABD3 KRAS PTP4A3 RAP2A RRAS2 SMG9 TLX3	108 interacting genes: ACTMAP ACY1 AKAP9 ANKRD10 ANKRD33 AOC1 APBB1IP ARMC5 ASB12 ATP6V0D1 B9D2 BPIFA1 C2orf42 CEACAM6 CFAP68 CIMIP2B CRX CSNK2B CTNNA3 DENND4A EFEMP2 ERAS FAM168B FCSK FNTB FOSB FOXH1 GGTLC2 GOLGA6L9 GTF2A1L H2BC11 HNF1B HNRNPUL1 HOPX HSPB2 HSPB2-C11orf52 HYI IGFL2 ING4 INTS11 IRF9 ITIH6 KCNJ5-AS1 KRT34 KRTAP11-1 KRTAP13-3 KRTAP19-1 KRTAP19-7 KRTAP3-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 LASP1 LMO2 MAGED1 MEIS1 METTL27 MORN5 MSX2 NDUFAB1 NFIC NFIX NHLRC4 NICN1 OIP5 PLA2G10 PLAAT1 POU2AF1 POU6F2 PPP1CC PQBP1 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB11 REL ROR2 RSKR SERPINE1 SLC15A2 SMU1 SNTA1 SP1 SPATA46 SPMIP9 SPRYD7 STH SYNGAP1 TBX22 TCIRG1 TEKT5 THTPA TLE2 TMEM42 TOX2 TP53BP1 TRIM42 UFSP1 WDR83 YPEL3 ZBTB32 ZNF34 ZNF41 ZNF44
Entrez ID		2342	30012
HPRD ID		00608	06868
Ensembl ID		ENSG00000257365	ENSG00000164438
Uniprot IDs		A0A384MEJ5 P49356	O43711
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?		GDP Binding G Protein Activity GTPase Activity GTP Binding Ras Protein Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Dynein Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Defense Response To Protozoan Regulation Of Rac Protein Signal Transduction Regulation Of Protein Localization To Membrane Microtubule Associated Complex Response To Protozoan Hydrolase Activity Protein-membrane Adaptor Activity Response To Mineralocorticoid L-serine-pyruvate Transaminase Activity Peptide Pheromone Maturation Alpha-tubulin Binding Hsp90 Protein Binding Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Glycine Biosynthetic Process, By Transamination Of Glyoxylate Oxalic Acid Secretion Microtubule Binding CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Regulation Of Microtubule-based Movement Protein Farnesyltransferase Activity Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Protein Farnesyltransferase Complex Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Glial Cell Development GTPase Complex Regulation Of Dendrite Morphogenesis Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Small GTPase Mediated Signal Transduction Glyoxylate Catabolic Process Alanine-glyoxylate Transaminase Activity Protein Farnesylation	Intermediate Filament Protein Binding Chromatin
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