FNTB and HDAC6

Number of citations of the paper that reports this interaction (PMID 19228685)
11

Data Source:
BioGRID (pull down)

		FNTB	HDAC6
Gene Name		farnesyltransferase, CAAX box, beta	histone deacetylase 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Microtubule Associated Complex Cytoplasmic Microtubule Caveola Inclusion Body Aggresome Dynein Complex Axon Dendrite Cell Leading Edge Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Farnesyltranstransferase Activity Protein Farnesyltransferase Activity Protein Binding Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	Core Promoter Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Enzyme Binding Polyubiquitin Binding Ubiquitin Protein Ligase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Phototransduction, Visible Light Negative Regulation Of Cell Proliferation Response To Inorganic Substance Response To Organic Cyclic Compound Rhodopsin Mediated Signaling Pathway Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway Response To Cytokine Wound Healing Positive Regulation Of Cell Cycle Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process	Protein Polyubiquitination Transcription, DNA-templated Protein Deacetylation Misfolded Or Incompletely Synthesized Protein Catabolic Process Intracellular Protein Transport Organelle Organization Negative Regulation Of Microtubule Depolymerization Response To Toxic Substance Positive Regulation Of Signal Transduction Response To Organic Substance Regulation Of Receptor Activity Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Receptor Biosynthetic Process Macroautophagy Histone Deacetylation Lysosome Localization Cellular Response To Heat Peptidyl-lysine Deacetylation Cellular Response To Topologically Incorrect Protein Regulation Of Gene Expression, Epigenetic Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Complex Disassembly Negative Regulation Of Protein Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Oxidoreductase Activity Response To Misfolded Protein Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Hsp90 Deacetylation Response To Growth Factor Histone H3 Deacetylation Histone H4 Deacetylation Cellular Response To Misfolded Protein Positive Regulation Of Chaperone-mediated Protein Complex Assembly Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction	HSF1 activation Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Assembly of the primary cilium Cellular response to heat stress Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517)
Protein-Protein Interactions		9 interactors: CENPF FNTA GBP1 HDAC6 HRAS KRAS PTP4A3 RAP2A RRAS2	67 interactors: ADRB2 ADRBK1 ATF3 ATXN3 AURKA BBS10 BCL3 BCOR BRMS1 CDKN1A CORD1 CSNK2A2 CTNNB1 CTTN CYLD EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB G3BP1 HDAC11 HES1 HIST4H4 HSP90AA1 JDP2 KPNA1 LCOR LPXN MAPK3 NACAD NASP NR0B2 NR3C1 PKN1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PTOV1 PXN RELB RUNX2 SIRT2 SYK TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2A TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H VCP VKORC1 ZBTB16 ZNF205
Entrez ID		2342	10013
HPRD ID		00608	02228
Ensembl ID		ENSG00000257365	ENSG00000094631
Uniprot IDs		P49356	Q9UBN7
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	3C5K 3GV4 3PHD
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Migration Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Cell Motility Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Locomotion Regulation Of Synaptic Transmission, GABAergic Regulation Of Cellular Component Movement Regulation Of Rac Protein Signal Transduction Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Regulation Of Neuron Death Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Light Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Response To External Stimulus Positive Regulation Of Locomotion Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Cellular Response To Organic Substance Regulation Of Oxidoreductase Activity Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Hsp90 Deacetylation Associative Learning Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Radiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Muscle Structure Development Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Receptor Activity Cell Communication Cellular Response To Growth Factor Stimulus Response To Organic Substance Learning Actin Cytoskeleton Organization	Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Transcription, DNA-templated Positive Regulation Of Protein Metabolic Process RNA Biosynthetic Process Protein Complex Assembly Positive Regulation Of Protein Modification Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Cellular Protein Modification Process Cellular Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression Protein Metabolic Process Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Heterocycle Metabolic Process Programmed Cell Death Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Death Defense Response Regulation Of Nitrogen Compound Metabolic Process Death Positive Regulation Of Transferase Activity Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response Mitotic Cell Cycle
Tagcloud ?		annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Difference) ?		annotation atad5 automatically becn1 cdkn2a centered clusterone cytoscape david e2f e2f1 geneways kegg kras language module modules mp neurofibromatosis nf1 nf2 nsclc orthologous phenotypes proven successively systemically thyroglobulin visualization	amplification classified clinicopathological correlated deacetylase deacetylation ductal entire hdac1 hdac2 hdac3 hdacs ihc improved luminal microarrays multiplication oncogenic os progesterone property scoring subtype supporting tumorigenesis tumors univariate younger
Tagcloud (Intersection) ?