PIWIL2 and TBCB

Number of citations of the paper that reports this interaction (PubMedID 28393858)
43

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PIWIL2	TBCB
Description		piwi like RNA-mediated gene silencing 2	tubulin folding cofactor B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Cell Cortex Microtubule Cytoskeleton Microtubule Plus-end
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding	Protein Binding Alpha-tubulin Binding Microtubule Plus-end Binding
	Biological Process	Regulation Of Translation Spermatogenesis Cell Differentiation Germ-line Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Negative Regulation Of Circadian Rhythm Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Secondary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated DNA Methylation Positive Regulation Of Cytoplasmic Translation	Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Nervous System Development Cell Differentiation Cytoplasmic Microtubule Organization
Pathways		PIWI-interacting RNA (piRNA) biogenesis	Post-chaperonin tubulin folding pathway
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: DDX4 DICER1 KRT8 RNF10 TBCB	4 interacting genes: GAN PIWIL2 TUBA4A USP7
Entrez ID		55124	1155
HPRD ID		11434	03196
Ensembl ID		ENSG00000197181	ENSG00000105254
Uniprot IDs		Q8TC59 W0HK13	Q99426
PDB IDs		3O7X 3QIR 7YFX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulatory RNA Binding Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Helicase Activity Peripheral Nervous System Myelin Formation Negative Regulation Of Nervous System Development Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulatory NcRNA-mediated Gene Silencing Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell Development RISC-loading Complex SiRNA Processing Pi-body Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Tubulin Complex Assembly RISC Complex Assembly SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Transposable Element Silencing By PiRNA-mediated DNA Methylation Pre-miRNA Processing Regulation Of Neurogenesis Myelin Assembly Hepatocyte Apoptotic Process PiRNA Processing P Granule Microtubule Plus-end Binding Regulation Of Nervous System Development Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development MiRNA Metabolic Process	Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Gene Expression, Epigenetic Rhythmic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Circadian Rhythm Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Epigenetic Regulation Of Gene Expression Perinucleolar Chromocenter Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By MRNA Destabilization Secondary PiRNA Processing PiRNA Binding Regulation Of Meiosis I Germ-line Stem Cell Population Maintenance PiRNA-mediated Gene Silencing By MRNA Destabilization PET Complex Dense Body Positive Regulation Of Meiosis I Pi-body Monoubiquitinated Protein Deubiquitination Hydrolase Activity DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Transposable Element Silencing By PiRNA-mediated DNA Methylation Chromatoid Body Negative Regulation Of Circadian Rhythm Regulation Of Telomere Capping Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Meiotic Nuclear Division K48-linked Deubiquitinase Activity PiRNA Processing Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Gluconeogenesis P Granule Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Positive Regulation Of Meiotic Cell Cycle Deubiquitinase Activity Positive Regulation Of Catabolic Process Protein Ubiquitination Regulation Of Meiotic Nuclear Division Chromatin Remodeling RNA Endonuclease Activity Regulation Of Cytoplasmic Translation DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Modification By Small Protein Conjugation Transposable Element Silencing
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