PIWIL2

Description		piwi like RNA-mediated gene silencing 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Perinucleolar Chromocenter Chromatoid Body P Granule Pi-body Dense Body PET Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Hydrolase Activity PiRNA Binding Metal Ion Binding
	Biological Process	Regulation Of Translation Spermatogenesis Cell Differentiation Germ-line Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing PiRNA Processing Negative Regulation Of Circadian Rhythm Oogenesis Rhythmic Process Meiotic Cell Cycle Positive Regulation Of Meiosis I Secondary PiRNA Processing PiRNA-mediated Gene Silencing By MRNA Destabilization Transposable Element Silencing By Heterochromatin Formation Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation Transposable Element Silencing By MRNA Destabilization Transposable Element Silencing By PiRNA-mediated DNA Methylation Positive Regulation Of Cytoplasmic Translation
Pathways		PIWI-interacting RNA (piRNA) biogenesis
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: DDX4 DICER1 KRT8 RNF10 TBCB
Entrez ID		55124
HPRD ID		11434
Ensembl ID		ENSG00000197181
Uniprot IDs		Q8TC59 W0HK13
PDB IDs		3O7X 3QIR 7YFX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Regulatory RNA Binding Regulation Of Gliogenesis Regulation Of Nervous System Process Negative Regulation Of Neurogenesis Helicase Activity Peripheral Nervous System Myelin Formation Negative Regulation Of Nervous System Development Global Gene Silencing By MRNA Cleavage Positive Regulation Of Schwann Cell Differentiation Ribonuclease III Activity Regulatory NcRNA-mediated Gene Silencing Regulation Of Schwann Cell Differentiation RNA Endonuclease Activity Producing 5'-phosphomonoesters, Hydrolytic Mechanism Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Deoxyribonuclease I Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell Development RISC-loading Complex SiRNA Processing Pi-body Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Pre-miRNA Binding Tubulin Complex Assembly RISC Complex Assembly SiRNA Binding TRNA Decay Apoptotic DNA Fragmentation Transposable Element Silencing By PiRNA-mediated DNA Methylation Pre-miRNA Processing Regulation Of Neurogenesis Myelin Assembly Hepatocyte Apoptotic Process PiRNA Processing P Granule Microtubule Plus-end Binding Regulation Of Nervous System Development Regulatory NcRNA-mediated Heterochromatin Formation Transposable Element Silencing By Heterochromatin Formation Apicolateral Plasma Membrane Cell Differentiation Involved In Embryonic Placenta Development MiRNA Metabolic Process
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