ATP13A2 and PSME3IP1

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	PSME3IP1
Description		ATPase cation transporting 13A2	proteasome activator subunit 3 interacting protein 1
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Protein Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Negative Regulation Of Protein Binding Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		Ion transport by P-type ATPases
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	7 interacting genes: ATP13A2 CSNK2A1 FZD7 LRRK2 MFHAS1 MTNR1B TRAF2
Entrez ID		23400	80011
HPRD ID		13677	11389
Ensembl ID		ENSG00000159363	ENSG00000172775
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	Q9GZU8
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES	7W59 7W5A
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Positive Regulation Of Cell Communication Negative Regulation Of Catabolic Process Cellular Response To Manganese Ion Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Response To Manganese Ion Regulation Of JNK Cascade Regulation Of Macroautophagy Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of Programmed Cell Death Vesicle Membrane Wnt Signaling Pathway Positive Regulation Of Signal Transduction Autophagy Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Macrophage Activation Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Autophagy TORC2 Complex Disassembly Negative Regulation Of Ectodermal Cell Fate Specification Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Protein Localization To Vacuole Positive Regulation Of Intracellular Signal Transduction TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Lysosome Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding
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