ATP13A2 and LMAN2

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	LMAN2
Description		ATPase cation transporting 13A2	lectin, mannose binding 2
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Cell Surface Membrane COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Protein Binding D-mannose Binding Carbohydrate Binding Heat Shock Protein Binding Metal Ion Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Phagocytosis
Pathways		Ion transport by P-type ATPases	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)	Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) High light scatter reticulocyte count ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494) Serum uric acid levels ( 30993211) Triglyceride levels ( 32203549) Urinary calcium excretion ( 31993563) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	4 interacting genes: ATP13A2 FRAT1 MAPK9 SUPT5H
Entrez ID		23400	10960
HPRD ID		13677	17285
Ensembl ID		ENSG00000159363	ENSG00000169223
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	A0A384NPY7 Q12907
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Regulation Of Protein Catabolic Process JUN Kinase Activity Protein Localization To Tricellular Tight Junction DSIF Complex Regulation Of Intracellular Protein Transport Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Cellular Response To Oxidative Stress Regulation Of Macroautophagy Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Autophagosome Size Cupric Ion Binding Polyamine Transmembrane Transport Cellular Response To Chemical Stress Regulation Of Intracellular Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion Positive Regulation Of Podosome Assembly ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Inflammatory Response To Wounding Response To Metal Ion Regulation Of Podosome Assembly Response To Manganese Ion Autophagosome-lysosome Fusion MAP Kinase Activity Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Autophagy Positive Regulation Of Exosomal Secretion Enzyme Binding Protein Localization To Cell-cell Junction Regulation Of Exosomal Secretion Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Protein Metabolic Process Regulation Of Protein Transport Cellular Response To Zinc Ion
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