ATP13A2 and GPR21

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	GPR21
Description		ATPase cation transporting 13A2	G protein-coupled receptor 21
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	G Protein-coupled Receptor Activity
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Glucose Homeostasis Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Ion transport by P-type ATPases
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	1 interacting genes: ATP13A2
Entrez ID		23400	2844
HPRD ID		13677	03551
Ensembl ID		ENSG00000159363	ENSG00000188394
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	B4DSD1 Q99679
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES	8HIX 8HJ0 8HJ1 8HJ2 8HMV
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Spermine Transmembrane Transport Cupric Ion Binding ABC-type Polyamine Transporter Activity Polyamine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Response To Zinc Ion Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Multivesicular Body Membrane Intracellular Zinc Ion Homeostasis Vesicle Membrane Response To Zinc Ion Multivesicular Body Regulation Of Autophagy Of Mitochondrion Autophagosome Membrane Protein Localization To Lysosome Manganese Ion Binding Intracellular Iron Ion Homeostasis Autophagosome Positive Regulation Of Exocytosis Lysosomal Lumen Protein Localization To Vacuole Organelle Membrane Fusion Autophagosome Organization Vesicle Fusion Transport Vesicle Regulation Of Mitochondrion Organization Lysosomal Transport Negative Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Intracellular Protein Transport Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein Localization To Nucleus
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