PSME3IP1 and FZD7

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PSME3IP1	FZD7
Description		proteasome activator subunit 3 interacting protein 1	frizzled class receptor 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endosome Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Frizzled Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Negative Regulation Of Protein Binding Negative Regulation Of Proteasomal Protein Catabolic Process	Regulation Of DNA-templated Transcription Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell-substrate Adhesion Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Wnt Signaling Pathway Stem Cell Population Maintenance Neuron Differentiation T Cell Differentiation In Thymus Substrate Adhesion-dependent Cell Spreading Non-canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Ectodermal Cell Fate Specification Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Somatic Stem Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Mesenchymal To Epithelial Transition Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Retinoic Acid Negative Regulation Of Cardiac Muscle Cell Differentiation
Pathways			Class B/2 (Secretin family receptors) PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 28869591 30598549) Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258) Total body bone mineral density ( 29304378)
Interacting Genes		7 interacting genes: ATP13A2 CSNK2A1 FZD7 LRRK2 MFHAS1 MTNR1B TRAF2	30 interacting genes: ADCY1 AIG1 AQP9 BCL2L13 CCDC88C CLN8 CLPTM1 DLG1 DLG2 DLG4 DVL1 FFAR2 GNAS HPCAL1 LEUTX MAGI3 MGST1 NCALD NCS1 PDAP1 PRNP PSME3IP1 SGTA SGTB SLC30A4 SLC35B1 TMEM237 UBQLN1 UBQLN2 UBQLN4
Entrez ID		80011	8324
HPRD ID		11389	04560
Ensembl ID		ENSG00000172775	ENSG00000155760
Uniprot IDs		Q9GZU8	O75084
PDB IDs		7W59 7W5A	4Z33 5T44 5URV 5WBS 6NE2 6NE4 6O3A 6O3B 8QEO 8YY8 9EPO 9EW2
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Negative Regulation Of Catabolic Process Cellular Response To Manganese Ion Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Response To Manganese Ion Regulation Of JNK Cascade Regulation Of Macroautophagy Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of Programmed Cell Death Vesicle Membrane Wnt Signaling Pathway Positive Regulation Of Signal Transduction Autophagy Regulation Of Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Macrophage Activation Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Autophagy TORC2 Complex Disassembly Negative Regulation Of Ectodermal Cell Fate Specification Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Protein Localization To Vacuole Positive Regulation Of Intracellular Signal Transduction TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Canonical Wnt Signaling Pathway Positive Regulation Of JNK Cascade Lysosome Polyamine Transmembrane Transporter Activity Extracellular Exosome Biogenesis Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding	Postsynaptic Density GMP Kinase Activity Ionotropic Glutamate Receptor Binding Regulation Of Proteolysis GDP Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Receptor Clustering TRC Complex Positive Regulation Of ERAD Pathway Membrane Ribonucleoside Diphosphate Metabolic Process Regulation Of ERAD Pathway Nucleoside Diphosphate Metabolic Process GMP Metabolic Process Dendritic Spine Organization Kinase Binding Frizzled Binding Postsynaptic Density Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Neuron Projection Organization D1 Dopamine Receptor Binding Postsynapse Organization Plasma Membrane Positive Regulation Of Neuron Projection Arborization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Or Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Proteolysis Social Behavior Purine Ribonucleotide Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Protein Localization To Synapse Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ribonucleotide Metabolic Process Establishment Or Maintenance Of Cell Polarity Juxtaparanode Region Of Axon Cytoplasmic Microtubule Organization Ribose Phosphate Metabolic Process Cognition Cellular Response To Metal Ion Immunological Synapse Formation Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Cellular Response To Potassium Ion Response To Metal Ion Nucleoside Monophosphate Metabolic Process
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