ATP13A2 and WDR5B

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	WDR5B
Description		ATPase cation transporting 13A2	WD repeat domain 5B
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Set1C/COMPASS Complex
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Histone Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Ion transport by P-type ATPases
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)	Calcium levels ( 20705733)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	2 interacting genes: ATP13A2 CFTR
Entrez ID		23400	54554
HPRD ID		13677	18302
Ensembl ID		ENSG00000159363	ENSG00000196981
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	Q86VZ2
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Regulation Of Exocytosis Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Protein Secretion Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Regulation Of Protein Secretion Positive Regulation Of Secretion Positive Regulation Of Anion Channel Activity Positive Regulation Of Secretion By Cell Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Transport Polyamine Transmembrane Transporter Activity Spermine Transport Extracellular Exosome Biogenesis P-type Transmembrane Transporter Activity Lysosomal Membrane Positive Regulation Of Enamel Mineralization ATP Hydrolysis Activity Extracellular Vesicle Biogenesis P-type Ion Transporter Activity Regulation Of Autophagosome Size Intracellular Monoatomic Ion Homeostasis Transepithelial Water Transport Intracellular Monoatomic Cation Homeostasis Negative Regulation Of Lysosomal Protein Catabolic Process Cupric Ion Binding Positive Regulation Of Protein Localization Regulation Of Protein Transport Monoatomic Ion Homeostasis Positive Regulation Of Tooth Mineralization Monoatomic Cation Homeostasis Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Polyamine Transmembrane Transport Bicarbonate Transmembrane Transporter Activity Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Intracellular PH Elevation Regulation Of Chaperone-mediated Autophagy Amelogenesis Regulation Of Vesicle-mediated Transport Cellular Response To Manganese Ion Regulation Of Secretion By Cell
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