ATP13A2 and ICAM2

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	ICAM2
Description		ATPase cation transporting 13A2	intercellular adhesion molecule 2
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Uropod Plasma Membrane Microvillus Membrane Cleavage Furrow Cell Projection Cell Periphery
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Integrin Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Cell Adhesion Cell-cell Adhesion
Pathways		Ion transport by P-type ATPases	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases		Parkinson's disease (PD)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	8 interacting genes: ATP13A2 CD209 EZR F2RL1 ITGAM ITGB2 MSN RDX
Entrez ID		23400	3384
HPRD ID		13677	00888
Ensembl ID		ENSG00000159363	ENSG00000108622
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	P13598 Q6FHE2
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES	1ZXQ
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Regulation Of Vesicle-mediated Transport Establishment Of Endothelial Barrier Endothelial Cell Development Regulation Of Protein Localization Positive Regulation Of Transport Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Endosome Regulation Of Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Component Size Cell Adhesion Molecule Binding Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Integrin AlphaM-beta2 Complex Epithelial Cell Development Regulation Of Superoxide Metabolic Process Regulation Of Cell Shape Regulation Of Transport Plasma Membrane Raft Positive Regulation Of Protein Localization Positive Regulation Of Neutrophil Degranulation Regulation Of Exocytosis Cell-cell Adhesion Positive Regulation Of Regulated Secretory Pathway Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Regulation Of Cell Morphogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process Microvillus Cytoskeletal Protein Binding Regulation Of Neutrophil Degranulation Regulation Of Intracellular Transport Microvillus Assembly Microvillus Organization Filopodium Positive Regulation Of Secretion By Cell Apical Part Of Cell Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Cell Periphery Complement Component C3b Binding Protein Kinase A Signaling Regulation Of Protein Catabolic Process Regulation Of Immune System Process Uropod Cell Adhesion
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