ATP13A2 and CXCR4

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		ATP13A2	CXCR4
Description		ATPase cation transporting 13A2	C-X-C motif chemokine receptor 4
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen	Cytoplasm Lysosome Endosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process	Response To Hypoxia Dendritic Cell Chemotaxis Apoptotic Process Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Response To Virus Cell Migration Calcium-mediated Signaling Neurogenesis Regulation Of Cell Adhesion Regulation Of Cell Migration Positive Regulation Of Cell Migration CXCL12-activated CXCR4 Signaling Pathway Myelin Maintenance Symbiont Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Vasculature Development Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway
Pathways		Ion transport by P-type ATPases	Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs			Baclofen Framycetin AMD-070 Plerixafor Ulocuplumab Ibalizumab MSX-122
Diseases		Parkinson's disease (PD)	Chemokine receptor defect, including the following disease: WHIM syndrome
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)	Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 19525953 31604244) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)
Interacting Genes		36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS	34 interacting genes: ARRB2 ATP13A2 B2M CCR5 CD4 CTSG CXCL12 DPP4 DUXAP9 ELANE GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RNF113A SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		23400	7852
HPRD ID		13677	01217
Ensembl ID		ENSG00000159363	ENSG00000121966
Uniprot IDs		Q8N4D4 Q8NBS1 Q9NQ11	A0A0U3FJG0 A0A0U3GXA9 A0A8Q3WLL1 P61073
PDB IDs		7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES	2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS 8GP3 8I0Q 8K3Z 8U4N 8U4O 8U4P 8U4Q 8U4R 8U4S 8U4T 8YU7 8ZPL 8ZPM 8ZPN
Enriched GO Terms of Interacting Partners?		Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity	Regulation Of Cell-cell Adhesion Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Immune System Process Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Via STAT Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Adhesion Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Activation Regulation Of Defense Response Positive Regulation Of T Cell Activation Response To Stress Defense Response Positive Regulation Of Immune System Process Interleukin-9-mediated Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of Multicellular Organismal Process Response To Other Organism Cell Activation Immune System Process Negative Regulation Of Leukocyte Cell-cell Adhesion Response To External Biotic Stimulus Regulation Of Cytokine Production Interleukin-15-mediated Signaling Pathway Leukocyte Activation Positive Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Cell Migration Regulation Of Leukocyte Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Population Proliferation Negative Regulation Of Leukocyte Activation Positive Regulation Of Cell Activation Leukocyte Mediated Cytotoxicity T Cell Activation Negative Regulation Of T Cell Activation Positive Regulation Of Immune Response Regulation Of Developmental Process Interleukin-6-mediated Signaling Pathway Regulation Of Multicellular Organismal Process
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