ICAM2 and ITGB2

Number of citations of the paper that reports this interaction (PubMedID 9786897)
0

Data Source:
HPRD (in vivo)

		ICAM2	ITGB2
Description		intercellular adhesion molecule 2	integrin subunit beta 2
Image
GO Annotations	Cellular Component	Uropod Plasma Membrane Microvillus Membrane Cleavage Furrow Cell Projection Cell Periphery	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Specific Granule Membrane Receptor Complex Plasma Membrane Raft Membrane Raft Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane Extracellular Vesicle
	Molecular Function	Integrin Binding	Amyloid-beta Binding Complement Component C3b Binding Integrin Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Heat Shock Protein Binding Cargo Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Cell-cell Adhesion	Microglial Cell Activation Leukocyte Migration Involved In Inflammatory Response Receptor-mediated Endocytosis Phagocytosis Phagocytosis, Engulfment Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Superoxide Anion Generation Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Endodermal Cell Differentiation Receptor Clustering Positive Regulation Of Neutrophil Degranulation Endothelial Cell Migration Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Dopamine Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Toll Like Receptor 4 (TLR4) Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS			Heel bone mineral density ( 28869591) Lymphocyte count ( 32888494) Neonatal white matter microstructure ( 33009551)
Interacting Genes		8 interacting genes: ATP13A2 CD209 EZR F2RL1 ITGAM ITGB2 MSN RDX	56 interacting genes: ADAMTSL4 APOL2 C3 CD14 CD226 CD82 COPS3 COPS5 CYSRT1 CYTH1 CYTH2 DAB1 DOK1 EGFR ESM1 FCER2 FHL2 FUT4 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 KRT31 KRTAP10-8 LHFPL5 MS4A7 MTIF3 NBPF19 NOTCH2NLA NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RACK1 RANBP9 RDX SCML1 SHARPIN SYK TLN1 TM4SF18 UPK1B VNN2
Entrez ID		3384	3689
HPRD ID		00888	02506
Ensembl ID		ENSG00000108622	ENSG00000160255
Uniprot IDs		P13598 Q6FHE2	A0A494C0X7 B4E0R1 P05107
PDB IDs		1ZXQ	1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72 4NEH 4NEN 5E6R 5E6S 5E6U 5E6V 5E6W 5E6X 5ES4 5XR1 5ZAZ 7P2D 7USL 7USM
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Establishment Of Endothelial Barrier Endothelial Cell Development Regulation Of Protein Localization Positive Regulation Of Transport Leukocyte Cell-cell Adhesion Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Endosome Regulation Of Cellular Localization Positive Regulation Of Exocytosis Regulation Of Cellular Component Size Cell Adhesion Molecule Binding Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Integrin AlphaM-beta2 Complex Epithelial Cell Development Regulation Of Superoxide Metabolic Process Regulation Of Cell Shape Regulation Of Transport Plasma Membrane Raft Positive Regulation Of Protein Localization Positive Regulation Of Neutrophil Degranulation Regulation Of Exocytosis Cell-cell Adhesion Positive Regulation Of Regulated Secretory Pathway Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Regulation Of Cell Morphogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process Microvillus Cytoskeletal Protein Binding Regulation Of Neutrophil Degranulation Regulation Of Intracellular Transport Microvillus Assembly Microvillus Organization Filopodium Positive Regulation Of Secretion By Cell Apical Part Of Cell Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Cell Periphery Complement Component C3b Binding Protein Kinase A Signaling Regulation Of Protein Catabolic Process Regulation Of Immune System Process Uropod Cell Adhesion	Integrin Binding Diacylglycerol-dependent Serine/threonine Kinase Activity Integrin-mediated Signaling Pathway Cell-cell Adhesion Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Plasma Membrane Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Protein Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Protein Phosphorylation Regulation Of Superoxide Metabolic Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Phosphorylation Immune Effector Process Signaling Receptor Binding Extracellular Exosome Enzyme Binding Response To Bacterium Immune Response-regulating Signaling Pathway Activation Of Immune Response Histone H3T6 Kinase Activity Focal Adhesion Positive Regulation Of Immune Response Regulation Of Cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Regulation Of Phagocytosis Positive Regulation Of Locomotion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?