NPFF and NPFFR2

Number of citations of the paper that reports this interaction (PubMedID 12609745)
0

Data Source:
HPRD (in vivo)

		NPFF	NPFFR2
Description		neuropeptide FF-amide peptide precursor	neuropeptide FF receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus Postsynapse Neuronal Dense Core Vesicle	Plasma Membrane Actin Cytoskeleton Membrane
	Molecular Function	G Protein-coupled Receptor Binding Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding Neuropeptide Activity	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Opioid Receptor Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Chemical Synaptic Transmission Response To Xenobiotic Stimulus Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Excitatory Postsynaptic Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: NPFFR1 NPFFR2 NPY ZDHHC17	6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1
Entrez ID		8620	10886
HPRD ID		06869	16244
Ensembl ID		ENSG00000139574	ENSG00000056291
Uniprot IDs		O15130	A0A804CC06 A0PJM9 Q9Y5X5
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Neuropeptide Receptor Activity G Protein-coupled Receptor Activity Short-day Photoperiodism Regulation Of MAPK Cascade Perforant Pathway To Dendrate Granule Cell Synapse G Protein-coupled Receptor Signaling Pathway Regulation Of Nerve Growth Factor Production Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Neuropeptide Y Receptor Binding Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Opioid Receptor Binding Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Eating Behavior Monocyte Activation Antifungal Humoral Response Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Signaling Receptor Binding Golgi-associated Vesicle Membrane Response To Yeast Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Response To Food Lipoprotein Transport Protein Palmitoylation Regulation Of Dopamine Metabolic Process Modulation Of Chemical Synaptic Transmission Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Intracellular Signal Transduction Regulation Of Feeding Behavior Photoperiodism Protein Lipidation Positive Regulation Of Behavior	Neuropeptide Hormone Activity Neuropeptide Signaling Pathway Regulation Of Response To Food Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Response To Nutrient Levels Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Regulation Of Neurotransmitter Secretion Feeding Behavior Type 2 Orexin Receptor Binding G Protein-coupled Receptor Binding Short-day Photoperiodism Regulation Of Postsynaptic Membrane Potential Regulation Of Secretion By Cell Regulation Of Nerve Growth Factor Production Neuropeptide Activity Somatostatin Secretion Cell-cell Signaling Cell Communication Regulation Of Secretion Signaling Neuropeptide Y Receptor Binding Perikaryon Vasopressin Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Perinuclear Region Of Cytoplasm Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Lumen Negative Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Positive Regulation Of Transmission Of Nerve Impulse Sleep Postsynapse Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Adult Feeding Behavior FK506 Binding Antifungal Humoral Response Intestinal Epithelial Cell Differentiation
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