NPFF and NPFFR2

Number of citations of the paper that reports this interaction (PMID 10851242)
20

Data Source:
HPRD (in vivo)

		NPFF	NPFFR2
Gene Name		neuropeptide FF-amide peptide precursor	neuropeptide FF receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Neuropeptide Hormone Activity	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Response To Peptide Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: NPFFR1 NPFFR2 NPY ZDHHC17	3 interactors: HCRT NPFF NPY
Entrez ID		8620	10886
HPRD ID		06869	16244
Ensembl ID		ENSG00000139574	ENSG00000056291
Uniprot IDs		O15130 Q3SXL4	A0PJM9 Q9Y5X5
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Synaptic Transmission Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Appetite Adult Feeding Behavior Regulation Of CAMP-dependent Protein Kinase Activity Response To Peptide Signal Transduction Regulation Of Response To Food Signaling Lipoprotein Transport Magnesium Ion Transport Cellular Response To Hormone Stimulus Cell Communication Regulation Of Appetite Protein Palmitoylation Cellular Response To Stimulus Response To Organonitrogen Compound Metal Ion Transport Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity	Neuropeptide Signaling Pathway Regulation Of Response To Food Regulation Of Appetite Synaptic Transmission Regulation Of Neurological System Process Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Feeding Behavior Cell-cell Signaling Membrane Depolarization G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Somatostatin Secretion Vasopressin Secretion Regulation Of Membrane Potential Cellular Calcium Ion Homeostasis Negative Regulation Of Transmission Of Nerve Impulse Calcium Ion Homeostasis Blood Circulation Positive Regulation Of Appetite Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Transmission Of Nerve Impulse Response To Nutrient Levels Cellular Cation Homeostasis Cellular Ion Homeostasis Acute Inflammatory Response To Antigenic Stimulus Response To Extracellular Stimulus Metal Ion Homeostasis Negative Regulation Of Heart Rate Adult Feeding Behavior Negative Regulation Of Appetite Regulation Of Transmission Of Nerve Impulse Cellular Chemical Homeostasis Ion Homeostasis Negative Regulation Of Neurological System Process Behavior Regulation Of Secretion Cell Surface Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Potassium Ion Transport Negative Regulation Of Heart Contraction Regulation Of Sensory Perception Of Pain Eating Behavior Chemical Homeostasis Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Blood Pressure
Tagcloud ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 npff2 npffr2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 npff2 npffr2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability