NPFF and NPY

Number of citations of the paper that reports this interaction (PMID 11325787)
8

Data Source:
HPRD (in vivo)

		NPFF	NPY
Gene Name		neuropeptide FF-amide peptide precursor	neuropeptide Y
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus	Extracellular Region Extracellular Space Cell Golgi Apparatus
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Neuropeptide Hormone Activity	G-protein Coupled Receptor Activity Receptor Binding Neuropeptide Hormone Activity Calcium Channel Regulator Activity Neuropeptide Y Receptor Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	Calcium Ion Transport Movement Of Cell Or Subcellular Component G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Synaptic Transmission Digestion Behavior Feeding Behavior Blood Circulation Regulation Of Blood Pressure Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Regulation Of Appetite Positive Regulation Of Appetite
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Periodontitis ( 23459936)
Protein-Protein Interactions		4 interactors: NPFFR1 NPFFR2 NPY ZDHHC17	15 interactors: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1
Entrez ID		8620	4852
HPRD ID		06869	01214
Ensembl ID		ENSG00000139574	ENSG00000122585
Uniprot IDs		O15130 Q3SXL4	A4D158 P01303
PDB IDs			1QFA 1RON
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Synaptic Transmission Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Appetite Adult Feeding Behavior Regulation Of CAMP-dependent Protein Kinase Activity Response To Peptide Signal Transduction Regulation Of Response To Food Signaling Lipoprotein Transport Magnesium Ion Transport Cellular Response To Hormone Stimulus Cell Communication Regulation Of Appetite Protein Palmitoylation Cellular Response To Stimulus Response To Organonitrogen Compound Metal Ion Transport Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity	Neuropeptide Signaling Pathway Feeding Behavior Cell-cell Signaling Synaptic Transmission G-protein Coupled Receptor Signaling Pathway Behavior Digestion Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Transport Negative Regulation Of Secretion Negative Regulation Of Feeding Behavior Outflow Tract Morphogenesis Peptide Hormone Secretion Peptide Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Hormone Secretion Regulation Of CAMP Biosynthetic Process Hormone Transport Cell Surface Receptor Signaling Pathway Peptide Transport Signal Transduction Regulation Of Secretion Regulation Of CAMP Metabolic Process Regulation Of Feeding Behavior Cellular Response To Stimulus Cardiac Left Ventricle Morphogenesis Response To Stimulus Membrane Depolarization Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Response To Food Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Signaling Positive Regulation Of Circadian Rhythm Amide Transport Regulation Of Appetite Cell Communication Multicellular Organismal Reproductive Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Multicellular Organism Reproduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Sensory Perception Of Pain Chemical Homeostasis Negative Regulation Of Secretion By Cell Metal Ion Homeostasis Cytosolic Calcium Ion Homeostasis Regulation Of Behavior Negative Regulation Of Insulin Secretion Regulation Of Cellular Localization
Tagcloud ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 npff2 npffr2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally neuropeptide pflugers ramiprilat renovascular tubular
Tagcloud (Difference) ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt nfatc1 npff2 npffr2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	anesthetized arch bischoff calciuresis concomitantly converting decline denervation diuresis excretion icatibant infusion intrarenal losartan magnified mediator michel micrograms microliter micromol mmhg modify natriuresis neuronally pflugers ramiprilat renovascular tubular
Tagcloud (Intersection) ?		neuropeptide