NPFF and NPFFR1

Number of citations of the paper that reports this interaction (PMID 11024015)
30

Data Source:
HPRD (in vivo, in vitro)

		NPFF	NPFFR1
Gene Name		neuropeptide FF-amide peptide precursor	neuropeptide FF receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Dendrite Vesicle Perikaryon Axon Terminus	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Neuropeptide Hormone Activity	G-protein Coupled Receptor Activity Neuropeptide Receptor Activity Peptide Binding
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Synaptic Transmission Negative Regulation Of Heart Rate Spinal Cord Development Vasopressin Secretion Negative Regulation Of Appetite Response To Drug Response To Morphine Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Regulation Of Sensory Perception Of Pain Regulation Of Excitatory Postsynaptic Membrane Potential Maternal Process Involved In Female Pregnancy Somatostatin Secretion	Neuropeptide Signaling Pathway Synaptic Transmission Biological_process Cellular Response To Hormone Stimulus Response To Peptide
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Orexin and neuropeptides FF and QRFP bind to their respective receptors GPCR ligand binding Metabolic disorders of biological oxidation enzymes G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23007406)
Protein-Protein Interactions		4 interactors: NPFFR1 NPFFR2 NPY ZDHHC17	1 interactors: NPFF
Entrez ID		8620	64106
HPRD ID		06869	12120
Ensembl ID		ENSG00000139574
Uniprot IDs		O15130 Q3SXL4	Q9GZQ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Neuropeptide Signaling Pathway Synaptic Transmission Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Appetite Adult Feeding Behavior Regulation Of CAMP-dependent Protein Kinase Activity Response To Peptide Signal Transduction Regulation Of Response To Food Signaling Lipoprotein Transport Magnesium Ion Transport Cellular Response To Hormone Stimulus Cell Communication Regulation Of Appetite Protein Palmitoylation Cellular Response To Stimulus Response To Organonitrogen Compound Metal Ion Transport Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity	Somatostatin Secretion Vasopressin Secretion Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Heart Rate Negative Regulation Of Appetite Regulation Of Response To Food Regulation Of Appetite Negative Regulation Of Heart Contraction Regulation Of Sensory Perception Of Pain Inflammatory Response To Antigenic Stimulus Regulation Of Membrane Depolarization Positive Regulation Of Blood Pressure Negative Regulation Of Insulin Secretion Response To Morphine Negative Regulation Of Peptide Secretion Regulation Of Neurological System Process Negative Regulation Of Hormone Secretion Peptide Hormone Secretion Peptide Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Acute Inflammatory Response Regulation Of Heart Rate Regulation Of Postsynaptic Membrane Potential Maternal Process Involved In Female Pregnancy Hormone Secretion Hormone Transport Response To Ammonium Ion Peptide Transport Neuropeptide Signaling Pathway Negative Regulation Of Protein Secretion Spinal Cord Development Membrane Depolarization Amide Transport Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Negative Regulation Of Secretion By Cell Regulation Of Heart Contraction Regulation Of Blood Pressure Negative Regulation Of Secretion Negative Regulation Of Protein Transport Cytosolic Calcium Ion Homeostasis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Female Pregnancy Regulation Of Hormone Secretion Regulation Of Hormone Levels Regulation Of Membrane Potential Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis
Tagcloud ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt neuropeptide nfatc1 npff2 npffr2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	amide analgesic arg carboxyl constitute emerging encoded kiss1r kisspeptin modulation modulatory mostly neuropeptide neuropeptides nh2 nociception opiates peptides phe prolactin pyroglutamylated qrfpr releasing reproduction rf rodents share
Tagcloud (Difference) ?		attenuate augmented beta3 cathepsin corning dependently griess intbeta3 integrin metallopeptidase modulates mtt nfatc1 npff2 osteo osteoclast osteoclastogenesis plates rank rankl raw264 resorption stain stripwell tartrate viability	amide analgesic arg carboxyl constitute emerging encoded kiss1r kisspeptin modulation modulatory mostly neuropeptides nh2 nociception opiates peptides phe prolactin pyroglutamylated qrfpr releasing reproduction rf rodents share
Tagcloud (Intersection) ?		neuropeptide npffr2