RPL13A and ALDH2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL13A	ALDH2
Description		ribosomal protein L13a	aldehyde dehydrogenase 2 family member
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse GAIT Complex Ribonucleoprotein Complex	Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Phenylacetaldehyde Dehydrogenase (NAD+) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor NAD Binding Carboxylesterase Activity
	Biological Process	Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Translation Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Homeostatic Process Macrophage Chemotaxis Lung Morphogenesis Cellular Response To Type II Interferon Negative Regulation Of Formation Of Translation Preinitiation Complex	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Metabolic Process Ethanol Catabolic Process Nitroglycerin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Regulation Of Dopamine Biosynthetic Process Regulation Of Serotonin Biosynthetic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Metabolism of serotonin Smooth Muscle Contraction Ethanol oxidation Mitochondrial protein degradation
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin	NADH Guanidine Disulfiram Daidzin Crotonaldehyde
Diseases			Acute alcohol sensitivity
GWAS		Hematological and biochemical traits ( 20139978) Monocyte count ( 32888494)	Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 31959922 28485404) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 29460428 24277619) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Alcohol drinking status (current drinker vs non-current drinker) ( 34073884) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Confectionary intake ( 33632354) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 28067908 26192919) Diastolic blood pressure ( 25249183 26390057) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407 23364009) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Excessive alcohol consumption ( 33093602) Fish consumption ( 32895509) Fish intake frequency ( 31959922) Gamma glutamyl transferase levels ( 33093602) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) hemolysis of donated blood (osmotic) ( 34014839) Hypertension ( 32709000 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tofu consumption ( 31959922) Triglycerides ( 26582766 22171074) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 34054925) Yoghurt consumption ( 31959922)
Interacting Genes		15 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FILNC1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN	15 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 OGT RPL13A SIRT3 SLC35F6 UNC119
Entrez ID		23521	217
HPRD ID		11775	00003
Ensembl ID		ENSG00000142541	ENSG00000111275
Uniprot IDs		A0A384ME37 P40429 Q8J015	A0A384NPN7 P05091
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13 8DR9 8SHS
Enriched GO Terms of Interacting Partners?			Synapse Regulation Of Glycolytic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Response To Unfolded Protein Protein-folding Chaperone Binding Apolipoprotein Binding Unfolded Protein Binding Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cellular Component Organization Protein Refolding Aminobutyraldehyde Dehydrogenase (NAD+) Activity 3-deoxyglucosone Dehydrogenase Activity Fructosamine Catabolic Process Acetaldehyde Dehydrogenase (NAD+) Activity Amyloid-beta Complex Regulation Of Synapse Assembly Growth Cone Lamellipodium Regulation Of Translation Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Folding Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Negative Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Lipid Biosynthetic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Translational Initiation Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Formation Of Translation Preinitiation Complex Regulation Of Phosphorus Metabolic Process Fructosamine Metabolic Process Acetylcholine Receptor Activator Activity Regulation Of Cell Junction Assembly Post-transcriptional Regulation Of Gene Expression Clathrin-coated Pit Lipoprotein Particle Mitochondrion Positive Regulation Of Protein Import Negative Regulation Of Caveolin-mediated Endocytosis Regulation Of Superoxide Dismutase Activity NAD-dependent Protein Lysine Delactylase Activity Negative Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Type II Interferon Production
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