RPL13A and CRP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RPL13A	CRP
Description		ribosomal protein L13a	C-reactive protein
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse GAIT Complex Ribonucleoprotein Complex	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding MRNA Binding Structural Constituent Of Ribosome	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Translation Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Homeostatic Process Macrophage Chemotaxis Lung Morphogenesis Cellular Response To Type II Interferon Negative Regulation Of Formation Of Translation Preinitiation Complex	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Classical antibody-mediated complement activation
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin	N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases			Systemic lupus erythematosus
GWAS		Hematological and biochemical traits ( 20139978) Monocyte count ( 32888494)	Blood protein levels ( 30072576 23696881) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		15 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FILNC1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN	22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A
Entrez ID		23521	1401
HPRD ID		11775	00422
Ensembl ID		ENSG00000142541	ENSG00000132693
Uniprot IDs		A0A384ME37 P40429 Q8J015	P02741 Q5VVP7
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5
Enriched GO Terms of Interacting Partners?			IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?