LARP1 and CLNS1A

Number of citations: 47 (PubMedID 37070251)
Data Source: BioGRID (affinity chromatography technology, unspecified method)

		LARP1	CLNS1A
Name		La ribonucleoprotein 1, translational regulator	chloride nucleotide-sensitive channel 1A
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane TORC1 Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Methylosome PICln-Sm Protein Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Activator Activity Translation Initiation Factor Binding Ribosomal Small Subunit Binding Cadherin Binding MRNA 5'-UTR Binding	RNA Binding Protein Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Cell Population Proliferation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Macroautophagy Negative Regulation Of Translation TOR Signaling TORC1 Signaling Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation MRNA Stabilization Cellular Response To Rapamycin Response To Amino Acid Starvation	Spliceosomal SnRNP Assembly MRNA Processing Chloride Transport Cell Volume Homeostasis RNA Splicing MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	snRNP Assembly
GWAS		Chin dimples ( 27182965 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Monobrow ( 27182965 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Diastolic blood pressure ( 30224653 ) Platelet distribution width ( 32888494 ) Tourette syndrome ( 30818990 )
Novel Interactors		4 novel interactors: ATP6AP1 LCP2 PPID PPL	1 novel interactors: ALK
Interacting Genes		13 interacting genes: BCL2L1 CEBPA CLNS1A CSNK2A1 KASH5 RNF10 SRPK1 TNNT1 UBXN7 YWHAB YWHAG YWHAQ YWHAZ	14 interacting genes: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 FRMD7 ITGA2B LARP1 LSM10 PRMT5 SNRPB SNRPD1 UBC WDR77
Entrez ID		23367	1207
HPRD ID		11225	03694
Ensembl ID		ENSG00000155506	ENSG00000074201
Uniprot IDs		A0A8I5KSP1 A0A8I5KWU3 Q6PKG0	E9PJF4 E9PMI6 J3KN38 P54105
PDB IDs		4ZC4 5C0V 5V4R 5V7C 5V87 6PW3 7SOO 7SOP 7SOQ 7SOR 7SOS 7SOT 7SOU 7SOV 7SOW 8EY6 8EY7 8EY8 8G90 8G91 8XP2 8XP3	6V0O 9E3A 9E3B
GO Terms Enriched among Interactors		Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Phosphoserine Residue Binding Establishment Of Protein Localization Intracellular Signal Transduction Identical Protein Binding Cytosol Positive Regulation Of Viral Genome Replication	Methylosome Spliceosomal SnRNP Assembly Histone Pre-mRNA DCP Binding U7 SnRNP U1 SnRNP Binding Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Regulation Of Dopamine Receptor Signaling Pathway U4 SnRNP Structural Constituent Of Cytoskeleton Small Nuclear Ribonucleoprotein Complex Regulation Of Translational Initiation SMN-Sm Protein Complex Macromolecule Methylation U1 SnRNP U5 SnRNP Cytosol U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Regulation Of Protein Localization To Cell Periphery Cortical Cytoskeleton Ribonucleoprotein Complex Cortical Actin Cytoskeleton Organization U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U2 SnRNP Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Methylation U4/U6 X U5 Tri-snRNP Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Response To Environmental Enrichment Negative Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cortical Cytoskeleton Organization Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Methylation Positive Regulation Of RNA Splicing Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Cytoplasmic U SnRNP Body RNA Binding Protein Metabolic Process MRNA Metabolic Process Regulation Of Norepinephrine Uptake Swimming Behavior Cytoskeletal Protein Binding U2 SnRNP Binding