LARP1 and UBXN7

Number of citations of the paper that reports this interaction (PubMedID 37744330)
51

Data Source:
BioGRID (unspecified method)

		LARP1	UBXN7
Description		La ribonucleoprotein 1, translational regulator	UBX domain protein 7
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane TORC1 Complex	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex
	Molecular Function	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Activator Activity Translation Initiation Factor Binding Ribosomal Small Subunit Binding Cadherin Binding MRNA 5'-UTR Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Translation Translational Initiation Regulation Of Translation Cell Population Proliferation Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Macroautophagy Negative Regulation Of Translation TOR Signaling TORC1 Signaling Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation MRNA Stabilization Cellular Response To Rapamycin Response To Amino Acid Starvation	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Chin dimples ( 27182965) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) IgM levels ( 28628107)
Interacting Genes		13 interacting genes: BCL2L1 CEBPA CLNS1A CSNK2A1 KASH5 RNF10 SRPK1 TNNT1 UBXN7 YWHAB YWHAG YWHAQ YWHAZ	34 interacting genes: APP CLEC19A CRX CYSRT1 DAZAP2 FAM120A FAM168A FLG IGF2BP1 IGF2BP2 IGF2BP3 LARP1 MAP3K1 MEOX1 MTDH MUL1 NEDD8 NFYC PABPC4 PAX5 PAX6 REL RNF111 RPS3 RPS3A SMURF1 TRAF6 TRIM39 TRIM62 TRIM8 UBC UBQLN1 UBQLN2 ZNRF1
Entrez ID		23367	26043
HPRD ID		11225	19396
Ensembl ID		ENSG00000155506	ENSG00000163960
Uniprot IDs		A0A8I5KSP1 A0A8I5KWU3 Q6PKG0	O94888
PDB IDs		4ZC4 5C0V 5V4R 5V7C 5V87 6PW3 7SOO 7SOP 7SOQ 7SOR 7SOS 7SOT 7SOU 7SOV 7SOW 8EY6 8EY7 8EY8 8G90 8G91 8XP2 8XP3	1WJ4 2DAL 2DLX 5X3P 5X4L
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Protein Targeting Protein Sequestering Activity Phosphoserine Residue Binding Establishment Of Protein Localization Intracellular Signal Transduction Identical Protein Binding Cytosol Positive Regulation Of Viral Genome Replication	Positive Regulation Of Macromolecule Metabolic Process MRNA 5'-UTR Binding Positive Regulation Of Metabolic Process Protein Metabolic Process Regulation Of Primary Metabolic Process Cytoplasmic Stress Granule Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Activity Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination CRD-mediated MRNA Stabilization N6-methyladenosine-containing RNA Reader Activity Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Base-excision Repair Macromolecule Metabolic Process Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction MRNA 3'-UTR Binding Translation Regulator Activity Cytosol Regulation Of RNA Metabolic Process Regulation Of Proteolysis MRNA Stabilization Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization NF-kappaB Complex Regulation Of Base-excision Repair Positive Regulation Of Protein Metabolic Process Negative Regulation Of Translation Nucleus Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of Gene Expression Protein Modification Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of MRNA Metabolic Process Cytoplasm Regulation Of RNA Stability Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process
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