PSD3 and ARAP1

Number of citations of the paper that reports this interaction (PubMedID 21275903)
45

Data Source:
BioGRID (two hybrid)

		PSD3	ARAP1
Description		pleckstrin and Sec7 domain containing 3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Ruffle Membrane Cell Projection Synapse	Ruffle Podosome Nucleoplasm Cytoplasm Endosome Early Endosome Multivesicular Body Golgi Apparatus Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Cell Projection Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Type 1 Angiotensin Receptor Binding Metal Ion Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction	Positive Regulation Of Receptor Recycling Regulation Of Receptor Internalization Actin Filament Organization Signal Transduction Regulation Of Cell Shape Regulation Of Endocytosis Regulation Of Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Bone Resorption Photoreceptor Cell Maintenance Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Filopodium Assembly Negative Regulation Of Stress Fiber Assembly
Pathways			PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Bone ultrasound measurement (velocity of sound) ( 28472463) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery disease ( 33020668) Erythrocyte cadmium concentration in never smokers ( 27005419) Glucose homeostasis traits ( 30576415) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longitudinal cocaine use ( 31591132) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Paclitaxel-induced neuropathy ( 23776197) Perceived intensity of fructose ( 31005972) Schizophrenia ( 30285260) Serum metabolite levels ( 33031748) Sub-cortical grey matter volume ( 31530798) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Trunk fat mass ( 28552196) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)	Acute insulin response ( 28490609) Alcohol dependence symptom count ( 29460428) Alloimmunization response to red blood cell transfusion in sickle cell anemia ( 25670933) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 28892062) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Fasting blood glucose ( 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycated hemoglobin levels ( 28898252) Household income (MTAG) ( 31844048) Insulin-related traits (multivariate analysis) ( 32002517) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Proinsulin levels ( 21873549) Rheumatoid arthritis ( 22446963) Type 2 diabetes ( 30297969 30718926 30054458 26961502 29358691 32499647 28869590 26818947 24509480 22885922) Waist circumference ( 28552196) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		4 interacting genes: ARAP1 MX1 SNCA UBC	15 interacting genes: APP ARIH2 ARPC3 CDC42 FGFR3 FILNC1 INPP5D KCTD12 PSD3 RAC1 TAB1 TES TP53BP1 WAPL XRCC6
Entrez ID		23362	116985
HPRD ID		11462	09440
Ensembl ID		ENSG00000156011	ENSG00000186635
Uniprot IDs		B3KRC4 B4DKF8 E5RJ29 Q9NYI0	E7EU13 Q96P48
PDB IDs			4X1V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Recycling Regulation Of Receptor Recycling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Regulation Of Norepinephrine Uptake Positive Regulation Of Endocytosis Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Presynapse Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Mitochondrial Outer Membrane Regulation Of Serotonin Uptake Type 1 Angiotensin Receptor Binding Microtubule Binding Dopamine Uptake Involved In Synaptic Transmission Interleukin-27-mediated Signaling Pathway Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Regulation Of Endocytosis Negative Regulation Of Oxidative Phosphorylation Extrinsic Component Of Plasma Membrane Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Type I Interferon SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Regulation Of Supramolecular Fiber Organization Regulation Of SNARE Complex Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport	Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Thioesterase Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Focal Adhesion Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Supramolecular Fiber Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Postsynapse Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Endocytosis Positive Regulation Of Lamellipodium Assembly GTP-dependent Protein Binding Phagocytosis, Engulfment Telomeric DNA Binding Hyperosmotic Response Response To X-ray Regulation Of Synaptic Vesicle Endocytosis Regulation Of Synaptic Vesicle Recycling Negative Regulation Of DNA Replication Intracellular Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Protein-containing Complex Cell Projection Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Innate Immune Response Regulation Of Lamellipodium Assembly Positive Regulation Of MAPK Cascade Protein Homooligomerization Neuron Projection Organization Intracellular Signaling Cassette Receptor Complex Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Dendrite Development Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling
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