PSD3

Description		pleckstrin and Sec7 domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Postsynaptic Density Membrane Ruffle Membrane Cell Projection Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Regulation Of ARF Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Bone ultrasound measurement (velocity of sound) ( 28472463) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery disease ( 33020668) Erythrocyte cadmium concentration in never smokers ( 27005419) Glucose homeostasis traits ( 30576415) HDL cholesterol levels in HIV infection ( 33109212) Heel bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Longitudinal cocaine use ( 31591132) Neutrophil count ( 21507922) Obesity-related traits ( 23251661) Paclitaxel-induced neuropathy ( 23776197) Perceived intensity of fructose ( 31005972) Schizophrenia ( 30285260) Serum metabolite levels ( 33031748) Sub-cortical grey matter volume ( 31530798) Survival in sporadic amyotrophic lateral sclerosis ( 27244217) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716 29403010 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Trunk fat mass ( 28552196) Urate levels in overweight individuals ( 25811787) Urinary albumin excretion rate in type 1 diabetes ( 24595857)
Interacting Genes		4 interacting genes: ARAP1 MX1 SNCA UBC
Entrez ID		23362
HPRD ID		11462
Ensembl ID		ENSG00000156011
Uniprot IDs		B3KRC4 B4DKF8 E5RJ29 Q9NYI0
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Receptor Recycling Regulation Of Receptor Recycling Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Supramolecular Fiber Organization Regulation Of Norepinephrine Uptake Positive Regulation Of Endocytosis Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Presynapse Negative Regulation Of Dopamine Metabolic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Mitochondrial Outer Membrane Regulation Of Serotonin Uptake Type 1 Angiotensin Receptor Binding Microtubule Binding Dopamine Uptake Involved In Synaptic Transmission Interleukin-27-mediated Signaling Pathway Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Cellular Respiration Regulation Of Endocytosis Negative Regulation Of Oxidative Phosphorylation Extrinsic Component Of Plasma Membrane Regulation Of Acyl-CoA Biosynthetic Process Supramolecular Fiber Catecholamine Uptake Dopamine Uptake Positive Regulation Of Inositol Phosphate Biosynthetic Process Response To Type I Interferon SNARE Complex Assembly Cellular Response To Epinephrine Stimulus Regulation Of Supramolecular Fiber Organization Regulation Of SNARE Complex Assembly Negative Regulation Of Microtubule Polymerization Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway ATP Synthesis Coupled Electron Transport
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