AKT3 and IWS1

Number of citations of the paper that reports this interaction (PubMedID 24462114)
39

Data Source:
BioGRID (enzymatic study)

		AKT3	IWS1
Description		AKT serine/threonine kinase 3	interacts with SUPT6H, CTD assembly factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Ciliary Basal Body	Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence	In Utero Embryonic Development Chromatin Remodeling MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus Regulation Of MRNA Processing MRNA Transport Transcription Elongation-coupled Chromatin Remodeling
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) ghrelin levels ( 33852427) Height ( 28552196) Menarche (age at onset) ( 23599027) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 25056061 23974872 28991256 30285260 29483656) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Cardiac troponin-I levels ( 31014085)
Interacting Genes		12 interacting genes: CRYAA FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2	10 interacting genes: AKT1 AKT3 CSNK2A1 ERCC6 ERICH2 KRTAP10-3 POLR2A STAT2 SUPT6H TCEA1
Entrez ID		10000	55677
HPRD ID		06441	07639
Ensembl ID		ENSG00000117020	ENSG00000163166
Uniprot IDs		A0A5F9ZHU3 A0A7P0TB32 A0A7P0TBJ6 Q9Y243	A0A1B0GW95 Q96ST2
PDB IDs		2X18 8ZXW	6EMR 6ZV1 6ZV4 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase Binding Regulation Of Intracellular Transport Protein Modification Process Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cytoplasm Regulation Of Protein Stability Sodium Channel Inhibitor Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Membrane Potential Regulation Of Neuron Projection Development Potassium Channel Inhibitor Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Nucleus Regulation Of Potassium Ion Export Across Plasma Membrane Cytosol Protein Metabolic Process Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Establishment Of Cell Polarity Regulation Of Monoatomic Cation Transmembrane Transport Vascular Endothelial Cell Response To Fluid Shear Stress	DNA-templated Transcription Elongation Transcription Elongation By RNA Polymerase II Negative Regulation Of PERK-mediated Unfolded Protein Response Double-strand Break Repair Via Classical Nonhomologous End Joining RNA Metabolic Process Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Recombination Sin3-type Complex Transcription Elongation Factor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Execution Phase Of Apoptosis Regulation Of Peptidyl-serine Phosphorylation Regulation Of DNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of Translational Initiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Response To Endoplasmic Reticulum Stress Nucleoplasm Regulation Of TRNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Blood Vessel Endothelial Cell Migration Nucleic Acid Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Insulin-like Growth Factor Stimulus Regulation Of Blood Vessel Endothelial Cell Migration Protein Serine Kinase Activity Mammalian Oogenesis Stage Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Gene Expression Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of Cell Cycle Phase Transition Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Kinase Binding
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