AKT3

Gene Name		v-akt murine thymoma viral oncogene homolog 3
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Mitochondrial Genome Maintenance Protein Phosphorylation Signal Transduction
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Regulation of beta-cell development PI3K/AKT activation PI-3K cascade Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR GPCR downstream signaling Signaling by VEGF AKT phosphorylates targets in the nucleus Downstream signal transduction Regulation of gene expression in beta cells Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System Costimulation by the CD28 family PIP3 activates AKT signaling VEGFA-VEGFR2 Pathway G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Downstream signaling of activated FGFR VEGFR2 mediated vascular permeability Programmed Cell Death Intrinsic Pathway for Apoptosis Innate Immune System Signalling by NGF CTLA4 inhibitory signaling AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Negative regulation of the PI3K/AKT network Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Menarche (age at onset) ( 23599027) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603)
Protein-protein Interactions		8 interactors: GSK3B NEDD4 NEDD4L PDPK1 PRKCD PRKCZ TCL1A TSC2
Entrez ID		10000
HPRD ID		06441
Ensembl ID		ENSG00000117020
Uniprot IDs		Q9Y243
PDB IDs		2X18
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Signaling Response To Growth Factor Negative Regulation Of Protein Phosphorylation Positive Regulation Of Transport Negative Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cellular Component Organization Negative Regulation Of Insulin Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Phospholipase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Transferase Activity Regulation Of Phospholipase Activity Negative Regulation Of Catalytic Activity Positive Regulation Of Lipase Activity Regulation Of Kinase Activity Regulation Of Signal Transduction Negative Regulation Of MAP Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transport Positive Regulation Of Hydrolase Activity Regulation Of Cellular Localization Regulation Of Protein Phosphorylation
Tagcloud ?		aberrant blot candidate downregulated dysregulation effectively exact forced hcc hepatocellular invasion inversely luciferase metastasis micrornas migration mir144 mirnas numerous overexpression remains reversed suppressed suppressive suppressor targeting tissues transfected unclear