ICOSLG and SH3GLB1

Data Source: HiPPIP (Novel)

		ICOSLG	SH3GLB1
Name		inducible T cell costimulator ligand	SH3 domain containing GRB2 like, endophilin B1
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Golgi Membrane Autophagosome Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Golgi Apparatus Cytosol Membrane Nuclear Body Midbody Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Receptor Ligand Activity	Fatty Acid Binding Protein Binding Lipid Binding Lysophosphatidic Acid Acyltransferase Activity Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Defense Response Hyperosmotic Response Signal Transduction Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway T Follicular Helper Cell Differentiation	Phosphatidic Acid Biosynthetic Process Autophagy Apoptotic Process Phospholipid Biosynthetic Process Positive Regulation Of Autophagy Regulation Of Macroautophagy Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Regulation Of Cytokinesis Receptor Catabolic Process Cellular Response To Amino Acid Starvation Cellular Response To Glucose Starvation Autophagic Cell Death 'de Novo' Post-translational Protein Folding Membrane Organization Membrane Fission Positive Regulation Of Membrane Tubulation Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Localization To Vacuolar Membrane Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Autophagosome Assembly
Pathways		Co-stimulation by ICOS	None
GWAS		Ankylosing spondylitis ( 23749187 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 22057235 ) Cerebral amyloid deposition (PET imaging) ( 30361487 ) Crohn's disease ( 21102463 18587394 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Inflammatory bowel disease ( 23128233 ) Left ventricular QRS voltage ( 27195777 ) Rheumatoid arthritis ( 30423114 ) Type 1 diabetes ( 25751624 34127860 ) Ulcerative colitis ( 21297633 )	No GWAS studies recorded
Novel Interactors		6 novel interactors: BACE2 DIP2A PPP2CB SGO1 SH3GLB1 SLC27A2	3 novel interactors: CSDE1 ICOSLG PCSK5
Interacting Genes		1 interacting genes: ICOS	52 interacting genes: ABHD5 ADAM15 ADAM9 AGTRAP AMPH APP ARFIP2 ARHGAP17 BAX BIN1 C1D CACFD1 CDKN2D CMTM5 COQ8A DESI2 DNM2 EXOSC5 F8A1 FAM114A2 FN1 FUNDC1 GADD45A GADD45G GSTP1 HTATIP2 HTT IRGM ITGB1BP2 MAL2 MTA1 PSMA1 RABAC1 RABGGTB RHEX RIC8A SH3GLB2 SH3KBP1 SIN3A SMIM5 SNX1 SNX4 SYNGR3 SYNJ1 SYP TAX1BP1 TFIP11 TPD52 TPD52L2 TTN UBL7 ZNF576
Entrez ID		23308	51100
HPRD ID		05757	15333
Ensembl ID		ENSG00000160223	ENSG00000097033
Uniprot IDs		A0A2R8Y5W7 A0A8V8TQV9 A0N0L8 B7Z1W8 O75144	A0A087WW40 A0A140VJU5 A0A994J549 Q9Y371
PDB IDs		6X4G 6X4T	6UP6 6UPN 9G2R 9G2U 9G2W
GO Terms Enriched among Interactors		Phosphate-containing Compound Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Organophosphate Biosynthetic Process Sulfur Compound Biosynthetic Process Cholate-CoA Ligase Activity Acyl-CoA Metabolic Process Ligase Activity Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Mitotic Sister Chromatid Cohesion, Centromeric Methyl-branched Fatty Acid Metabolic Process Amide Biosynthetic Process Acetate-CoA Ligase Activity 'de Novo' Post-translational Protein Folding Spindle Pole Chromosome, Centromeric Region Autophagic Cell Death Regulation Of Neurofibrillary Tangle Assembly Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Positive Regulation Of Protein Acetylation T Cell Tolerance Induction Phosphatidylinositol 3-kinase Activator Activity Purine-containing Compound Biosynthetic Process Organophosphate Metabolic Process Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Sulfur Compound Metabolic Process Long-chain Fatty Acid Import Into Cell Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process T Follicular Helper Cell Differentiation Lysophosphatidic Acid Acyltransferase Activity 'de Novo' Protein Folding Nucleoside Phosphate Biosynthetic Process Lipid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Acetyl-CoA Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Meiotic Chromosome Segregation Centriole-centriole Cohesion Long-chain Fatty Acid-CoA Ligase Activity FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Long-chain Fatty Acid Transmembrane Transporter Activity Dendritic Spine Morphogenesis Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process	Cytoplasmic Vesicle Protein Binding SH3 Domain Binding Synaptic Vesicle Vesicle-mediated Transport Insulin Receptor Binding Leptin Receptor Binding Endocytosis Integrin Binding BH3 Domain Binding Cytoplasm Synaptic Vesicle Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Positive Regulation Of Programmed Cell Death Peptidase Activator Activity Positive Regulation Of Catabolic Process Establishment Of Vesicle Localization