ICOSLG and SGO1

		ICOSLG	SGO1
Description		inducible T cell costimulator ligand	shugoshin 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding Kinase Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Defense Response Hyperosmotic Response Signal Transduction Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway T Follicular Helper Cell Differentiation	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Co-stimulation by ICOS	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576) Celiac disease ( 20190752 22057235) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 21102463 18587394) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		1 interacting genes: ICOS	21 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6
Entrez ID		23308	151648
HPRD ID		05757	12377
Ensembl ID		ENSG00000160223	ENSG00000129810
Uniprot IDs		A0A2R8Y5W7 A0A8V8TQV9 A0N0L8 B7Z1W8 O75144	B5BUA4 Q5FBB7
PDB IDs		6X4G 6X4T	3FGA 3Q6S 4A0I 7ZJS
Enriched GO Terms of Interacting Partners?		Phosphate-containing Compound Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Organophosphate Biosynthetic Process Sulfur Compound Biosynthetic Process Cholate-CoA Ligase Activity Acyl-CoA Metabolic Process Ligase Activity Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Mitotic Sister Chromatid Cohesion, Centromeric Methyl-branched Fatty Acid Metabolic Process Amide Biosynthetic Process Acetate-CoA Ligase Activity 'de Novo' Post-translational Protein Folding Spindle Pole Chromosome, Centromeric Region Autophagic Cell Death Regulation Of Neurofibrillary Tangle Assembly Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Positive Regulation Of Protein Acetylation T Cell Tolerance Induction Phosphatidylinositol 3-kinase Activator Activity Purine-containing Compound Biosynthetic Process Organophosphate Metabolic Process Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Sulfur Compound Metabolic Process Long-chain Fatty Acid Import Into Cell Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process T Follicular Helper Cell Differentiation Lysophosphatidic Acid Acyltransferase Activity 'de Novo' Protein Folding Nucleoside Phosphate Biosynthetic Process Lipid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Acetyl-CoA Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Meiotic Chromosome Segregation Centriole-centriole Cohesion Long-chain Fatty Acid-CoA Ligase Activity FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Long-chain Fatty Acid Transmembrane Transporter Activity Dendritic Spine Morphogenesis Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation
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