ICOSLG and DIP2A

		ICOSLG	DIP2A
Description		inducible T cell costimulator ligand	disco interacting protein 2 homolog A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome	Mitochondrion Plasma Membrane Cell Surface Membrane Cell Projection Dendritic Spine Synapse
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Receptor Ligand Activity	Acetate-CoA Ligase Activity Protein Binding Ligase Activity
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Defense Response Hyperosmotic Response Signal Transduction Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway T Follicular Helper Cell Differentiation	Acetyl-CoA Biosynthetic Process Nervous System Development Negative Regulation Of Gene Expression Dendritic Spine Morphogenesis Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		Co-stimulation by ICOS
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576) Celiac disease ( 20190752 22057235) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 21102463 18587394) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624 34127860) Ulcerative colitis ( 21297633)	Anti-saccade response ( 29064472) Lymphocyte count ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 30224653) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: ICOS	20 interacting genes: ADAMTSL4 ATOSB CCDC33 CEP44 DAB2 DLX2 DSCAM GPATCH2L IQUB JMJD6 MBIP PSME3 PTPN3 SORBS3 STAC3 TLE5 TMCC2 TRIM39 TRIP13 ZBTB43
Entrez ID		23308	23181
HPRD ID		05757	07611
Ensembl ID		ENSG00000160223	ENSG00000160305
Uniprot IDs		A0A2R8Y5W7 A0A8V8TQV9 A0N0L8 B7Z1W8 O75144	A0A494C143 Q14689 Q96NX2
PDB IDs		6X4G 6X4T
Enriched GO Terms of Interacting Partners?		Phosphate-containing Compound Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Organophosphate Biosynthetic Process Sulfur Compound Biosynthetic Process Cholate-CoA Ligase Activity Acyl-CoA Metabolic Process Ligase Activity Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Mitotic Sister Chromatid Cohesion, Centromeric Methyl-branched Fatty Acid Metabolic Process Amide Biosynthetic Process Acetate-CoA Ligase Activity 'de Novo' Post-translational Protein Folding Spindle Pole Chromosome, Centromeric Region Autophagic Cell Death Regulation Of Neurofibrillary Tangle Assembly Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Positive Regulation Of Protein Acetylation T Cell Tolerance Induction Phosphatidylinositol 3-kinase Activator Activity Purine-containing Compound Biosynthetic Process Organophosphate Metabolic Process Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Sulfur Compound Metabolic Process Long-chain Fatty Acid Import Into Cell Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process T Follicular Helper Cell Differentiation Lysophosphatidic Acid Acyltransferase Activity 'de Novo' Protein Folding Nucleoside Phosphate Biosynthetic Process Lipid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Acetyl-CoA Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Meiotic Chromosome Segregation Centriole-centriole Cohesion Long-chain Fatty Acid-CoA Ligase Activity FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Long-chain Fatty Acid Transmembrane Transporter Activity Dendritic Spine Morphogenesis Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process
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