ICOSLG

Description		inducible T cell costimulator ligand
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Defense Response Hyperosmotic Response Signal Transduction Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway T Follicular Helper Cell Differentiation
Pathways		Co-stimulation by ICOS
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576) Celiac disease ( 20190752 22057235) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 21102463 18587394) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624 34127860) Ulcerative colitis ( 21297633)
Novel Interacting Genes		6 novel interacting genes: BACE2 DIP2A PPP2CB SGO1 SH3GLB1 SLC27A2
Interacting Genes		1 interacting genes: ICOS
Entrez ID		23308
HPRD ID		05757
Ensembl ID		ENSG00000160223
Uniprot IDs		A0A2R8Y5W7 A0A8V8TQV9 A0N0L8 B7Z1W8 O75144
PDB IDs		6X4G 6X4T
Enriched GO Terms of Interacting Partners?		Phosphate-containing Compound Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Organophosphate Biosynthetic Process Sulfur Compound Biosynthetic Process Cholate-CoA Ligase Activity Acyl-CoA Metabolic Process Ligase Activity Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Membrane Tubulation Protein Localization To Vacuolar Membrane Mitotic Sister Chromatid Cohesion, Centromeric Methyl-branched Fatty Acid Metabolic Process Amide Biosynthetic Process Acetate-CoA Ligase Activity 'de Novo' Post-translational Protein Folding Spindle Pole Chromosome, Centromeric Region Autophagic Cell Death Regulation Of Neurofibrillary Tangle Assembly Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid Catabolic Process Fatty Acid Alpha-oxidation Positive Regulation Of Protein Acetylation T Cell Tolerance Induction Phosphatidylinositol 3-kinase Activator Activity Purine-containing Compound Biosynthetic Process Organophosphate Metabolic Process Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Sulfur Compound Metabolic Process Long-chain Fatty Acid Import Into Cell Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process T Follicular Helper Cell Differentiation Lysophosphatidic Acid Acyltransferase Activity 'de Novo' Protein Folding Nucleoside Phosphate Biosynthetic Process Lipid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Acetyl-CoA Biosynthetic Process Negative Regulation Of Glycoprotein Biosynthetic Process Meiotic Chromosome Segregation Centriole-centriole Cohesion Long-chain Fatty Acid-CoA Ligase Activity FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Long-chain Fatty Acid Transmembrane Transporter Activity Dendritic Spine Morphogenesis Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Amyloid Precursor Protein Biosynthetic Process
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