ICOSLG

Gene Name		inducible T-cell co-stimulator ligand
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding
	Biological Process	Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation
Pathways		Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-protein Interactions		1 interactors: ICOS
Entrez ID		23308
HPRD ID		05757
Ensembl ID		ENSG00000160223
Uniprot IDs		A0N0L8 K4DIA0 O75144
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Tolerance Induction Tolerance Induction T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Development
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable enah eventually identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation