ICOSLG and ICOS

Number of citations of the paper that reports this interaction (PMID 11023515)
37

Data Source:
HPRD (in vitro)

		ICOSLG	ICOS
Gene Name		inducible T-cell co-stimulator ligand	inducible T-cell co-stimulator
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Binding
	Biological Process	Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation	T Cell Tolerance Induction Immune Response Single Organismal Cell-cell Adhesion T Cell Costimulation
Pathways		Costimulation by the CD28 family Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 18587394 21102463) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)	Alopecia areata ( 20596022) Celiac disease ( 20190752) Obesity-related traits ( 23251661)
Protein-Protein Interactions		1 interactors: ICOS	2 interactors: ICOSLG WIF1
Entrez ID		23308	29851
HPRD ID		05757	09196
Ensembl ID		ENSG00000160223	ENSG00000163600
Uniprot IDs		A0N0L8 K4DIA0 O75144	Q53QY6 Q9Y6W8
PDB IDs
Enriched GO Terms of Interacting Partners?		T Cell Tolerance Induction Tolerance Induction T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Development
Tagcloud ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable enah eventually identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics
Tagcloud (Difference) ?		atf4 biomarkers chek2 computational concept conjunction datasets downregulated druggable enah eventually identifying implicate jimt methodology preclinical progress proof rad51 reproducibly restored rigorous rigorously skbr3 subpathways transcriptomic trastuzumab upregulated validation	aberrant adaptive attributed b7 beneficial blockade blocking cd28 checkpoints combinatorial contributions ctla evasion exceptionally existing h4 immunity immunotherapies immunotherapy investigating microenvironment monotherapies pd prompting rely responsiveness restore substantial therapeutics
Tagcloud (Intersection) ?