BICD2 and DCTN2

Number of citations of the paper that reports this interaction (PMID 11483508)
62

Data Source:
HPRD (in vitro, in vivo)

		BICD2	DCTN2
Gene Name		bicaudal D homolog 2 (Drosophila)	dynactin 2 (p50)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Plasma Membrane Cytoplasmic Vesicle	Kinetochore Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Rab GTPase Binding	Motor Activity Protein Binding Spectrin Binding
	Biological Process	Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Organelle Organization Mitotic Spindle Organization Mitotic Nuclear Division Metabolic Process Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System
Drugs
Diseases
GWAS		Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		5 interactors: DCTN1 DCTN2 GSK3B NEK9 RAB6A	21 interactors: BICD1 BICD2 BLOC1S6 CALM1 CCDC172 DISC1 EGFR GADD45A GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MARCKSL1 PAFAH1B1 RPGR ZW10
Entrez ID		23299	10540
HPRD ID		09826	09568
Ensembl ID		ENSG00000185963	ENSG00000175203
Uniprot IDs		Q8TD16 Q96FU2	Q13561
PDB IDs
Enriched GO Terms of Interacting Partners?		Melanosome Transport Pigment Granule Transport Antigen Processing And Presentation Cell Cycle Process Establishment Of Melanosome Localization Mitotic Nuclear Division Melanosome Localization Cell Cycle Cellular Pigmentation Retrograde Transport, Endosome To Golgi Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II ER-nucleus Signaling Pathway Mitotic Cell Cycle Process Pigmentation Establishment Of Localization In Cell G2/M Transition Of Mitotic Cell Cycle Microtubule-based Transport Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Microtubule-based Process Immune System Process Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Response To Endoplasmic Reticulum Stress Cellular Localization Minus-end-directed Organelle Transport Along Microtubule Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Peptidyl-cysteine Methylation Establishment Of Vesicle Localization Vesicle Localization Endosomal Transport Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Antigen Processing And Presentation Of Peptide Antigen Cellular Response To Interleukin-3 Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Protein Localization To Microtubule Microtubule-based Movement Negative Regulation Of Dendrite Morphogenesis Establishment Of Organelle Localization Negative Regulation Of NFAT Protein Import Into Nucleus ER Overload Response Early Endosome To Golgi Transport Negative Regulation Of Cardiac Muscle Hypertrophy	Microtubule-based Process Microtubule Cytoskeleton Organization Cellular Localization Microtubule-based Transport Protein Localization Cytoskeleton-dependent Intracellular Transport Movement Of Cell Or Subcellular Component Microtubule-based Movement Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Protein Localization Organelle Organization Establishment Of Localization In Cell Intracellular Transport Minus-end-directed Organelle Transport Along Microtubule Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Development Cerebral Cortex Development Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Organelle Transport Along Microtubule Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Generation Of Neurons Neuron Differentiation Cytoskeleton Organization Pallium Development Forebrain Development Cell Projection Organization Neurotrophin TRK Receptor Signaling Pathway Brain Development Cellular Response To Mechanical Stimulus Neurogenesis Neurotrophin Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Head Development Neuron Projection Development Nervous System Development Regulation Of ERBB Signaling Pathway Microtubule Anchoring At Microtubule Organizing Center Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Phospholipase Activity Protein Localization To Organelle Cerebral Cortex Cell Migration Fc Receptor Signaling Pathway Cell Cycle Telencephalon Cell Migration Telencephalon Development
Tagcloud ?		associates bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll1 dynll2 dynlrb1 dynlrb2 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Difference) ?		associates bona chains cilia ciliopathies ciliopathy define dynactin dynein dynll1 dynll2 dynlrb1 dynlrb2 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60
Tagcloud (Intersection) ?