BICD2 and YTHDF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		BICD2	YTHDF1
Description		BICD cargo adaptor 2	YTH N6-methyladenosine RNA binding protein F1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Annulate Lamellae Nuclear Pore Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Vesicle	P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Cytoskeletal Anchor Activity Small GTPase Binding Dynactin Binding Dynein Light Intermediate Chain Binding Dynein Complex Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Protein Transport Protein Localization To Golgi Apparatus MRNA Transport Centrosome Localization Regulation Of Microtubule Cytoskeleton Organization Minus-end-directed Organelle Transport Along Microtubule Microtubule Anchoring At Microtubule Organizing Center	Immune System Process Regulation Of Antigen Processing And Presentation Learning Memory Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation MRNA Destabilization Organelle Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of Axon Guidance
Pathways		COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Haemorrhoidal disease ( 33888516) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Neutrophil count ( 32888494) Platelet count ( 32888494) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)	Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		51 interacting genes: ARHGAP45 CBR3 CCDC187 CCHCR1 DCTN1 DCTN2 DCX DSCR9 FAM110A FAM161A FAM161B FAM50B GSK3B HDAC4 LNX1 MFAP1 MOS NEK9 NXF1 PCM1 PMF1 POLDIP3 PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 RAB6A RAB6B RBM22 RBM41 SNW1 TBRG4 TCEA2 TCEANC TFIP11 TSGA10IP USP2 UTP14A UTP14C YES1 YTHDF1 ZC2HC1C ZMAT2 ZNF417 ZNF624 ZNF648 ZNF669 ZNF670 ZSCAN12 ZSCAN23	42 interacting genes: ABHD11 BATF2 BICD2 C6orf15 CFTR CLK2 CPSF7 CTTN DMRTB1 DYNC1I1 ERI3 FAM168A FHIT HEY1 HSF4 ITSN2 KRTAP13-1 KRTAP26-1 KRTAP7-1 KRTAP8-1 LASP1 MAGED1 MOV10 MSX2 OIP5 PPIL3 PRR32 PRRC2B QKI RBFOX2 RBM22 RBMS3 RBPMS SARNP SF1 SNCA SNRPA TLE5 TMED9 VPS37C XRN2 ZNF34
Entrez ID		23299	54915
HPRD ID		09826	11691
Ensembl ID		ENSG00000185963	ENSG00000149658
Uniprot IDs		Q8TD16 Q96FU2	Q9BYJ9
PDB IDs		6OFP 6PSE	4RCI 4RCJ 7PCU 7QKN 7QL7 7YYE 7YYF 7YYJ 7YZ8 8BS4
Enriched GO Terms of Interacting Partners?		Centrosome Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Processing U4/U6 X U5 Tri-snRNP Complex RNA Metabolic Process MRNA Metabolic Process U2-type Precatalytic Spliceosome Ciliary Basal Body Nuclear Speck Microtubule Cytoskeleton Organization Microtubule Anchoring Protein Localization To Golgi Membrane Catalytic Step 2 Spliceosome Spindle Microtubule Nucleoplasm Protein Binding Microtubule Anchoring At Centrosome Nucleus Microtubule-based Process Nucleic Acid Metabolic Process Microtubule Anchoring At Microtubule Organizing Center Microtubule Binding Cellular Response To Retinoic Acid Myosin V Binding Establishment Of Organelle Localization Zinc Ion Binding Spindle Pole Spliceosomal Tri-snRNP Complex Assembly Centriole Nucleic Acid Binding Positive Regulation Of Protein Export From Nucleus U5 SnRNP	Nucleic Acid Binding MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome MRNA Metabolic Process Negative Regulation Of Biosynthetic Process RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Binding
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