PHLPP1 and CSNK1A1

Number of citations of the paper that reports this interaction (PMID 19797085)
27

Data Source:
BioGRID (enzymatic study)

		PHLPP1	CSNK1A1
Gene Name		PH domain and leucine rich repeat protein phosphatase 1	casein kinase 1, alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Membrane	Condensed Chromosome Kinetochore Cytoplasm Centrosome Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Membrane Nuclear Speck Primary Cilium
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Binding Metal Ion Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Entrainment Of Circadian Clock Dephosphorylation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Protein Phosphorylation Phagocytosis Mitotic Nuclear Division Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Shape Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cell Division Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Negative regulation of the PI3K/AKT network Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated Hedgehog 'on' state XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome Activation of SMO
Drugs
Diseases
GWAS			Esophageal cancer ( 21642993)
Protein-Protein Interactions		4 interactors: CSNK1A1 GSK3B USP1 USP46	43 interactors: ACTB ADAP1 AP3B1 AP3B2 APC AXIN1 BID CDC25A CHRM3 CREM CTNNB1 EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MAPT MDM4 NFATC3 PARK2 PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 RCC1 SLC18A2 SNCA SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 YWHAQ YWHAZ
Entrez ID		23239	1452
HPRD ID		15145	02739
Ensembl ID		ENSG00000081913	ENSG00000113712
Uniprot IDs		O60346	B4DER9 P48729 Q6PJ06 Q71TU5
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Deubiquitination Peptidyl-serine Phosphorylation Protein Modification By Small Protein Removal Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Regulation Of Canonical Wnt Signaling Pathway Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cellular Response To Interleukin-3 Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Synaptic Transmission Righting Reflex Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Cellular Protein Metabolic Process Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Monoubiquitinated Protein Deubiquitination Regulation Of Protein Catabolic Process ER Overload Response Adult Feeding Behavior Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Behavioral Response To Ethanol Regulation Of Cell Morphogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Modification-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of DNA Methylation Myoblast Fusion Reflex Protein Localization To Cytoskeleton Protein Catabolic Process Regulation Of Proteolysis	Death Apoptotic Process Programmed Cell Death Cell Death Cellular Response To Stimulus Regulation Of Cellular Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Signaling Positive Regulation Of Cell Death Response To Organic Substance Response To Stimulus Cell Communication Regulation Of Apoptotic Process Response To Stress Regulation Of Cell Death Regulation Of Protein Localization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cellular Process Regulation Of Signaling Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Transport Execution Phase Of Apoptosis Response To External Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cell Death Immune System Process Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Establishment Of Protein Localization Developmental Process Thymus Development Regulation Of Catalytic Activity Signal Transduction Cellular Response To Organic Substance Positive Regulation Of Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Protein Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway T Cell Differentiation In Thymus Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Regulation Of Cellular Protein Metabolic Process Leukocyte Activation Positive Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component
Tagcloud ?		alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Difference) ?		alphat alphatp angiogenesis biochem dissociation hek293 heterodimer htap htap1 inactive inc lipid location mediator overexpressed periodicals phosphatidylinositol pi3kgamma pkb reactivated sec14l2 sensor stimulates tocopherol tocopheryl translate vasculogenesis vegf wiley	aberrantly antagonistic beauty becomes canonical concert connectivity ctnnb1 decipher discover facts functioning gbm gli2 hedgehog imperative integrative interplay missed ranked recapitulate relying shh similarities smo solve sonic surmised wnt
Tagcloud (Intersection) ?