PHLPP1 and WDR48

Number of citations of the paper that reports this interaction (PubMedID 33397691)
84

Data Source:
BioGRID (affinity chromatography technology, pull down, proximity labelling technology)

		PHLPP1	WDR48
Description		PH domain and leucine rich repeat protein phosphatase 1	WD repeat domain 48
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Lysosome Endosome Late Endosome Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding Deubiquitinase Activator Activity Ubiquitin Binding
	Biological Process	Regulation Of T Cell Anergy Apoptotic Process Entrainment Of Circadian Clock Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of JNK Cascade Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of P38MAPK Cascade	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Single Fertilization Male Gonad Development Multicellular Organism Growth Skin Development Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Embryonic Organ Development Skeletal System Morphogenesis Homeostasis Of Number Of Cells Positive Regulation Of Epithelial Cell Proliferation Regulation Of Macromolecule Metabolic Process Seminiferous Tubule Development Regulation Of Primary Metabolic Process Regulation Of Protein Monoubiquitination Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Negative regulation of the PI3K/AKT network	Recognition of DNA damage by PCNA-containing replication complex Ub-specific processing proteases Fanconi Anemia Pathway Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)	Metabolic syndrome ( 31589552) Social communication problems ( 24564958)
Interacting Genes		6 interacting genes: BRAP CSNK1A1 GSK3B NHERF1 TRIM11 WDR48	7 interacting genes: NMRAL1 PAXIP1 PCNA PHLPP1 RAD51 UBC USP1
Entrez ID		23239	57599
HPRD ID		15145	11146
Ensembl ID		ENSG00000081913	ENSG00000114742
Uniprot IDs		O60346	A0A024R2L1 Q8TAF3
PDB IDs			5CVL 5CVN 5CVO 5K1A 5K1B 5K1C 5L8E 5L8W 6JLQ 7AY0 7AY1 7AY2 8A9J 8A9K 9EBS 9HNW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Negative Regulation Of Protein-containing Complex Assembly Maintenance Of Cell Polarity Negative Regulation Of Wnt Signaling Pathway Viral Protein Processing Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytoplasm Negative Regulation Of TOR Signaling TOR Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein-containing Complex Assembly Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Establishment Of Cell Polarity Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome Positive Regulation Of Platelet-derived Growth Factor Production Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Renal Phosphate Ion Absorption Negative Regulation Of AIM2 Inflammasome Complex Assembly Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Platelet-derived Growth Factor Production Type 3 Metabotropic Glutamate Receptor Binding Regulation Of TOR Signaling Negative Regulation Of Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Negative Regulation Of Cell Communication Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Viral Process Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Protein Modification Process Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cilium Negative Regulation Of TORC2 Signaling Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Dopaminergic Neuron Differentiation Cellular Response To Interleukin-3 Regulation Of Glycogen (starch) Synthase Activity	Regulation Of DNA Metabolic Process Response To Radiation DNA Repair DNA Polymerase Binding Replication Fork Processing DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Repair Male Germ Cell Nucleus DNA Damage Response PCNA Complex Replisome Response To Glucoside Positive Regulation Of Error-prone Translesion Synthesis PCNA-p21 Complex Telomere Maintenance DNA Polymerase Processivity Factor Activity Regulation Of DNA Biosynthetic Process Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleic Acid Metabolic Process Mitotic Recombination-dependent Replication Fork Processing DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton Spermatocyte Division Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Chorion Development Regulation Of Cellular Response To Stress Telomere Organization Positive Regulation Of DNA Repair Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Regulation Of DNA Recombination Cellular Response To Cisplatin Response To Ionizing Radiation LncRNA Transcription Response To UV DNA Strand Invasion DNA Recombinase Assembly Cellular Response To Camptothecin Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Radiation Nuclear Ubiquitin Ligase Complex Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Chromosome, Telomeric Region MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication
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