NUP210 and EXOSC5

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		NUP210	EXOSC5
Gene Name		nucleoporin 210kDa	exosome component 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Exosome (RNase Complex) Nucleus Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin
	Molecular Function	Protein Dimerization Activity	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Carbohydrate Metabolic Process Mitotic Nuclear Envelope Disassembly Hexose Transport Pathogenesis Gene Expression Regulation Of Glucose Transport Protein Transport Glucose Transport Viral Process Viral Life Cycle Viral Transcription Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process MRNA Transport Transmembrane Transport	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Mitotic Prophase HIV Infection Nuclear import of Rev protein Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Nuclear Envelope Breakdown SLC-mediated transmembrane transport M Phase Influenza Life Cycle HIV Life Cycle Influenza Viral RNA Transcription and Replication Rev-mediated nuclear export of HIV RNA Myoclonic epilepsy of Lafora Glycogen storage diseases Transcriptional regulation by small RNAs Vpr-mediated nuclear import of PICs ISG15 antiviral mechanism Interferon Signaling Host Interactions of HIV factors Nuclear Pore Complex (NPC) Disassembly Regulation of Glucokinase by Glucokinase Regulatory Protein Cytokine Signaling in Immune system Interactions of Vpr with host cellular proteins Interactions of Rev with host cellular proteins Influenza Infection Hexose transport Cell Cycle, Mitotic Late Phase of HIV Life Cycle Antiviral mechanism by IFN-stimulated genes Viral Messenger RNA Synthesis Metabolism of carbohydrates Glucose transport	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CDK1 EXOSC5 TRIP6	32 interactors: BIRC2 CALCOCO2 CDK5RAP1 DHRS2 DIS3 DOCK8 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FCHO1 GOLGA2 IKZF3 KIAA1217 KRT13 LIPG LSM5 MPP6 NUP210 PA2G4 PKM POLR2L REL SFPQ SKIV2L2 TNFAIP1 TRIM54 ZNF558
Entrez ID		23225	56915
HPRD ID		06368	16222
Ensembl ID		ENSG00000132182	ENSG00000077348
Uniprot IDs		Q8TEM1	M0R050 Q9NQT4
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Pronuclear Fusion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Protein Transport Regulation Of Schwann Cell Differentiation Regulation Of Intracellular Transport DNA Deamination Protein Localization To Kinetochore Protein Localization To Chromosome, Centromeric Region Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Protein Transport Regulation Of Protein Import Into Nucleus, Translocation Mitotic G2 DNA Damage Checkpoint Ventricular Cardiac Muscle Cell Development Regulation Of Establishment Of Protein Localization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Response To Copper Ion Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Transport Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Protein Localization Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Positive Regulation Of Intracellular Signal Transduction Ventricular Cardiac Muscle Cell Differentiation Protein Localization To Chromosome Positive Regulation Of Cardiac Muscle Cell Proliferation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Macromolecule Catabolic Process Focal Adhesion Assembly G2 DNA Damage Checkpoint Mitotic Nuclear Envelope Disassembly Positive Regulation Of Heart Growth Positive Regulation Of Transcription Factor Import Into Nucleus Histone Phosphorylation Regulation Of NF-kappaB Import Into Nucleus Nuclear Envelope Disassembly Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Cellular Localization Adherens Junction Assembly DNA Metabolic Process Peptidyl-threonine Phosphorylation Chromosome Condensation	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic RRNA Processing RRNA Metabolic Process Ribosome Biogenesis Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay NcRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process Ribonucleoprotein Complex Biogenesis MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process RRNA Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic RNA Metabolic Process Maturation Of 5.8S RRNA Nuclear MRNA Surveillance Aromatic Compound Catabolic Process RNA Surveillance Cellular Macromolecule Catabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression RNA Phosphodiester Bond Hydrolysis Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Intracellular MRNA Localization Nuclear Polyadenylation-dependent TRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription U4 SnRNA 3'-end Processing Nucleic Acid Phosphodiester Bond Hydrolysis TRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) SnoRNA Metabolic Process RRNA 3'-end Processing Cellular Metabolic Process RNA Localization DNA Deamination Immune System Process Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Immune Response Leukocyte Activation Isotype Switching
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