FLT1 and NRP2

Number of citations of the paper that reports this interaction (PMID 11278319)
19

Data Source:
HPRD (in vivo)

		FLT1	NRP2
Gene Name		fms-related tyrosine kinase 1	neuropilin 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Receptor Complex	Semaphorin Receptor Complex Extracellular Region Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding VEGF-A-activated Receptor Activity VEGF-B-activated Receptor Activity Placental Growth Factor-activated Receptor Activity Identical Protein Binding	Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Heparin Binding Semaphorin Receptor Activity Growth Factor Binding Cytokine Binding Metal Ion Binding
	Biological Process	Patterning Of Blood Vessels Sprouting Angiogenesis Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Axon Guidance Positive Regulation Of Endothelial Cell Migration Nerve Development Vascular Endothelial Growth Factor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Involved In Axon Guidance Sympathetic Ganglion Development Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Neurophilin interactions with VEGF and VEGFR	Axon guidance Signaling by VEGF Neurophilin interactions with VEGF and VEGFR L1CAM interactions NrCAM interactions
Drugs		Sorafenib Sunitinib Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib
Diseases
GWAS		Cognitive performance ( 19734545) Coronary heart disease ( 23364394)
Protein-Protein Interactions		24 interactors: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	8 interactors: FLT1 NRP1 PGF SEMA3B SEMA3C SEMA3F SEMA4F VEGFA
Entrez ID		2321	8828
HPRD ID		01297	03643
Ensembl ID		ENSG00000102755	ENSG00000118257
Uniprot IDs		L7RSL3 P17948	O60462 Q7LBX6 Q7Z3T9
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG	2QQJ 2QQK 2QQL 2QQO
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Signal Transduction Response To Organic Substance Regulation Of Intracellular Signal Transduction Locomotion Signaling Cell Communication Cellular Response To Peptide Hormone Stimulus Anatomical Structure Morphogenesis Cellular Response To Peptide Cell Migration Innate Immune Response Response To Stress Cell Motility Cell Development Regulation Of Signal Transduction Cellular Response To Stimulus Fc Receptor Signaling Pathway Blood Vessel Morphogenesis Cellular Response To Hormone Stimulus Cell Differentiation Immune Response Regulation Of Immune System Process Blood Coagulation Hemostasis Defense Response Positive Regulation Of MAPK Cascade Anatomical Structure Development Regulation Of MAPK Cascade Angiogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Neuron Differentiation Regulation Of Signaling Response To Peptide Immune System Process Cell Activation Blood Vessel Development Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Vasculature Development	Chemotaxis Axon Guidance Sprouting Angiogenesis Axonogenesis Axon Development Regulation Of Axon Extension Morphogenesis Of A Branching Epithelium Cell Morphogenesis Involved In Neuron Differentiation Morphogenesis Of A Branching Structure Locomotion Neuron Projection Morphogenesis Anatomical Structure Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Cell Morphogenesis Involved In Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Projection Morphogenesis Negative Regulation Of Axon Extension Cell Part Morphogenesis Regulation Of Cell Size Positive Regulation Of Retinal Ganglion Cell Axon Guidance VEGF-activated Neuropilin Signaling Pathway Neuron Development Response To External Stimulus Regulation Of Axonogenesis Cellular Response To Vascular Endothelial Growth Factor Stimulus Pattern Specification Process Ameboidal-type Cell Migration Cell Differentiation Cell Morphogenesis Blood Vessel Development Morphogenesis Of An Epithelium Neuron Differentiation Vasculature Development Cell Projection Organization Branching Morphogenesis Of An Epithelial Tube Patterning Of Blood Vessels Neural Crest Cell Migration Regulation Of Retinal Ganglion Cell Axon Guidance Tissue Morphogenesis Positive Regulation Of Endothelial Cell Proliferation System Development Negative Regulation Of Axonogenesis Neural Crest Cell Development Tube Development Coronary Artery Morphogenesis Regulation Of Developmental Growth Trigeminal Nerve Structural Organization
Tagcloud ?		abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide	10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Difference) ?		abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide	10a 200c 30a 30c arhgap5 cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3
Tagcloud (Intersection) ?