FLT1 and FLT3

Data Source: HiPPIP (Novel)

		FLT1	FLT3
Name		fms related receptor tyrosine kinase 1	fms related receptor tyrosine kinase 3
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Receptor Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Endosome Membrane Membrane Protein-containing Complex Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Placental Growth Factor Receptor Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Nuclear Glucocorticoid Receptor Binding Protein-containing Complex Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Monocyte Chemotaxis Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Lymphocyte Proliferation Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation Liver Regeneration
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Selpercatinib	Sorafenib Sunitinib XL999 Tandutinib Linifanib Lestaurtinib Midostaurin Ponatinib Nintedanib Pacritinib Tivozanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases		None	Acute myeloid leukemia (AML)
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 ) Body mass index ( 26426971 ) Cognitive performance ( 19734545 ) Coronary artery disease ( 29212778 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 23364394 ) Myocardial infarction ( 33532862 ) Refractive error ( 32231278 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Triglyceride levels ( 32203549 )	Apolipoprotein A1 levels ( 32203549 ) Autoimmune thyroid disease ( 32581359 ) Basophil count ( 32888494 ) Body mass index ( 25673413 29273807 ) Body size at age 10 ( 32376654 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Monocyte count ( 29403010 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Non-albumin protein levels ( 29403010 ) Pancreatic cancer ( 25086665 ) Plateletcrit ( 32888494 ) Psoriasis ( 25854761 ) Rapid automised naming of digits ( 30741946 ) Serum total protein levels ( 29403010 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Tourette syndrome ( 30818990 ) White blood cell count ( 27863252 32888494 ) White blood cell count (monocyte) ( 28158719 )
Novel Interactors		8 novel interactors: ALOX5AP ARL2BP CDK8 FLT3 HMGB1 LATS2 MIPEP RASSF9	8 novel interactors: CDK8 FLT1 FMO1 GPR12 NFIB PNPLA3 SHC1 SNRPA1
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	18 interacting genes: CBL CBLB CTNNB1 ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		2321	2322
HPRD ID		01297	00635
Ensembl ID		ENSG00000102755	ENSG00000122025
Uniprot IDs		L7RSL3 P17948	P36888
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89	1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR 7QDP 7ZV9 8XB1
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Locomotion Phosphotyrosine Residue Binding Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Chemotaxis Response To Growth Factor Vascular Endothelial Growth Factor Receptor Activity Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Immune System Process Regulation Of Epithelial Cell Proliferation	Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Lymphocyte Activation Ephrin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Activation ERBB Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus SH3 Domain Binding Response To Growth Factor Negative Regulation Of Leukocyte Activation Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Cell Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Neutrophil Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Neutrophil Activation T Cell Receptor Signaling Pathway T Cell Costimulation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion