FLT1

Gene Name		fms-related tyrosine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Endosome Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding VEGF-A-activated Receptor Activity VEGF-B-activated Receptor Activity Placental Growth Factor-activated Receptor Activity Identical Protein Binding
	Biological Process	Patterning Of Blood Vessels Sprouting Angiogenesis Monocyte Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis
Pathways		VEGF binds to VEGFR leading to receptor dimerization VEGF ligand-receptor interactions Signaling by VEGF Neurophilin interactions with VEGF and VEGFR
Drugs		Sorafenib Sunitinib Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib
Diseases
GWAS		Cognitive performance ( 19734545) Coronary heart disease ( 23364394)
Protein-protein Interactions		24 interactors: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		2321
HPRD ID		01297
Ensembl ID		ENSG00000102755
Uniprot IDs		L7RSL3 P17948
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Signal Transduction Response To Organic Substance Regulation Of Intracellular Signal Transduction Locomotion Signaling Cell Communication Cellular Response To Peptide Hormone Stimulus Anatomical Structure Morphogenesis Cellular Response To Peptide Cell Migration Innate Immune Response Response To Stress Cell Motility Cell Development Regulation Of Signal Transduction Cellular Response To Stimulus Fc Receptor Signaling Pathway Blood Vessel Morphogenesis Cellular Response To Hormone Stimulus Cell Differentiation Immune Response Regulation Of Immune System Process Blood Coagulation Hemostasis Defense Response Positive Regulation Of MAPK Cascade Anatomical Structure Development Regulation Of MAPK Cascade Angiogenesis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Neuron Differentiation Regulation Of Signaling Response To Peptide Immune System Process Cell Activation Blood Vessel Development Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation Cell Morphogenesis Involved In Differentiation Vasculature Development
Tagcloud ?		abstract bace2 cleaving consecutively eclampsia endoglin eng fms fourth gynecology hif1a hypertensive hypoxia longitudinal mif milan multisystem obstetrics onwards pe pregnancies principally raffaele reaching sampled san seemed singleton worldwide