FLT1

Description		fms related receptor tyrosine kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Placental Growth Factor Receptor Activity
	Biological Process	Angiogenesis Sprouting Angiogenesis Monocyte Chemotaxis Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Selpercatinib
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Myocardial infarction ( 33532862) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)
Novel Interacting Genes		8 novel interacting genes: ALOX5AP ARL2BP CDK8 FLT3 HMGB1 LATS2 MIPEP RASSF9
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1
Entrez ID		2321
HPRD ID		01297
Ensembl ID		ENSG00000102755
Uniprot IDs		L7RSL3 P17948
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Locomotion Phosphotyrosine Residue Binding Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Chemotaxis Response To Growth Factor Vascular Endothelial Growth Factor Receptor Activity Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Immune System Process Regulation Of Epithelial Cell Proliferation
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