FLT1 and MIPEP

		FLT1	MIPEP
Description		fms related receptor tyrosine kinase 1	mitochondrial intermediate peptidase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Receptor Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Placental Growth Factor Receptor Activity	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Angiogenesis Sprouting Angiogenesis Monocyte Chemotaxis Chemotaxis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Blood Vessel Morphogenesis Embryonic Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Vascular Endothelial Cell Proliferation Hyaloid Vascular Plexus Regression	Proteolysis Peptide Metabolic Process Protein Processing Involved In Protein Targeting To Mitochondrion
Pathways		Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization
Drugs		Sorafenib Sunitinib Vatalanib TG-100801 OSI-930 Denibulin Linifanib IMC-1C11 Pazopanib Axitinib N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Regorafenib Lenvatinib Nintedanib Polaprezinc Foreskin fibroblast (neonatal) Tivozanib Fostamatinib Selpercatinib
Diseases
GWAS		Acute respiratory distress syndrome in sepsis ( 31982041) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 26426971) Cognitive performance ( 19734545) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 23364394) Myocardial infarction ( 33532862) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549)	Femur bone mineral density x serum urate levels interaction ( 34046847) Fourth ventricle volume ( 31530798) Lung cancer ( 21725308) Myopia (pathological) ( 21640322) Venous thromboembolism ( 32232851) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		25 interacting genes: ATR CRK CTNNB1 FYN GRB2 KDR NCK1 NEDD4 NRP1 NRP2 PGF PIK3R1 PLCG1 PLCG2 PTK2 PTK2B PTPN11 SHC1 SHC2 SRPK1 STAT1 STAT3 VEGFA VEGFB YES1	2 interacting genes: ILK MAPK6
Entrez ID		2321	4285
HPRD ID		01297	03761
Ensembl ID		ENSG00000102755	ENSG00000027001
Uniprot IDs		L7RSL3 P17948	Q99797
PDB IDs		1FLT 1QSV 1QSZ 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Signal Transduction Cell Migration Positive Regulation Of Cell Population Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Angiogenesis Regulation Of Vasculature Development Positive Regulation Of Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Cell Motility Positive Regulation Of Locomotion Phosphotyrosine Residue Binding Regulation Of Cell Migration Regulation Of MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Regulation Of Endothelial Cell Proliferation Regulation Of Cell Motility Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation ERBB Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Neurotrophin TRKA Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Chemotaxis Response To Growth Factor Vascular Endothelial Growth Factor Receptor Activity Cell Differentiation Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Immune System Process Regulation Of Epithelial Cell Proliferation	Protein Kinase Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway ATP Binding Positive Regulation Of Developmental Process Protein Localization To Cell Cortex Septin Cytoskeleton Nucleotide Binding Tube Morphogenesis Hyaloid Vascular Plexus Regression Vascular Endothelial Growth Factor Receptor Activity Protein Phosphorylation Actin Cytoskeleton Phosphorylation Focal Adhesion Plasma Membrane Raft Assembly Protein Serine/threonine Kinase Activity Caveola Assembly Negative Regulation Of Vascular Endothelial Cell Proliferation Protein Kinase Binding Anatomical Structure Regression Membrane Raft Assembly Plasma Membrane Raft Organization Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Developmental Process Schwann Cell Development Fibroblast Migration Myelination In Peripheral Nervous System MAP Kinase Activity Kinase Activity Monocyte Chemotaxis Negative Regulation Of Neural Precursor Cell Proliferation Membrane Raft Organization Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Positive Regulation Of MAP Kinase Activity Sprouting Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Vascular Endothelial Cell Proliferation Growth Factor Binding Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Migration Peptidyl-tyrosine Phosphorylation Branching Involved In Ureteric Bud Morphogenesis Nerve Development Intracellular Signaling Cassette Establishment Or Maintenance Of Apical/basal Cell Polarity Platelet Aggregation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
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