PACS1

Gene Name		phosphofurin acidic cluster sorting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol COPI-coated Vesicle
	Molecular Function	Protein Binding Ion Channel Binding
	Biological Process	Protein Targeting To Golgi Viral Process Regulation Of Defense Response To Virus By Virus Protein Targeting To Plasma Membrane
Pathways		Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Nef mediated downregulation of MHC class I complex cell surface expression
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Obesity (early onset extreme) ( 23563609)
Protein-protein Interactions		10 interactors: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		55690
HPRD ID		06320
Ensembl ID		ENSG00000175115
Uniprot IDs		Q6VY07
PDB IDs
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Catabolic Process Liver Development Cell Death Death Cell Surface Receptor Signaling Pathway Response To Reactive Oxygen Species Regulation Of Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Apoptotic Mitochondrial Changes Phosphate-containing Compound Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Cellular Response To Potassium Ion Starvation Negative Regulation Of Cellular Protein Catabolic Process Apoptotic Process Cellular Response To Organic Substance Programmed Cell Death Regulation Of Endothelial Cell Proliferation Response To Oxidative Stress Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Cellular Protein Modification Process Response To Inorganic Substance Protein Kinase D Signaling Leading Edge Cell Differentiation Nerve Growth Factor Production Metanephric Smooth Muscle Tissue Development Detection Of Nodal Flow Renal Artery Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Gland Development Regulation Of Receptor Activity Positive Regulation Of Metabolic Process Negative Regulation Of Protein Catabolic Process Transport Response To Hydrogen Peroxide Negative Regulation Of Transforming Growth Factor Beta1 Production
Tagcloud ?		acidic adaptor adaptors amyloidogenic app breakdown breaks cathepsin cation cytosolic endosomes golgi hallmark impairs inability investigating mannose phosphofurin prevents proper repeats routing shuttles sorla sort sorting studying tgn unexplored