ANKLE2 and ZFYVE9

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		ANKLE2	ZFYVE9
Description		ankyrin repeat and LEM domain containing 2	zinc finger FYVE-type containing 9
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding	Protein Binding 1-phosphatidylinositol Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Mitotic Nuclear Membrane Reassembly Nervous System Development Central Nervous System Development Nuclear Membrane Reassembly Negative Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Cell Division	Endocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Endosomal Transport
Pathways		Initiation of Nuclear Envelope (NE) Reformation RAC2 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Adult body size ( 32376654) Immune response to smallpox vaccine (IL-6) ( 22542470) Lymphocyte count ( 32888494) Refractive error ( 32231278)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: MAPK13 ZFYVE9 ZNF512B	38 interacting genes: ANKLE2 BAG6 BMP4 CHD6 CLTC CTNNB1 DAZAP2 EIF4G1 ERBIN ETS2 FHL2 JUP LRP12 NIT1 NUP155 PML PPP1CA PPP1CB PPP1CC PPP2R1A RBBP6 RHOT2 RNF11 RNPEP SCYL2 SMAD2 SMAD3 SPART ST7 SUMF2 SUPT5H SVEP1 TENT5A TGFBR1 TGFBR2 UBC UBXN11 ZMYND8
Entrez ID		23141	9372
HPRD ID		19309	04782
Ensembl ID		ENSG00000176915	ENSG00000157077
Uniprot IDs		Q86XL3	O95405
PDB IDs			1DEV 1MK2 4BKW 5MJY
Enriched GO Terms of Interacting Partners?		Response To Anisomycin Cellular Response To Anisomycin Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sorbitol Cellular Response To Sodium Arsenite Response To Sorbitol MAP Kinase Activity Cellular Response To Arsenic-containing Substance 1-phosphatidylinositol Binding Response To Salt Response To Arsenic-containing Substance Stress-activated Protein Kinase Signaling Cascade Stress-activated MAPK Cascade Negative Regulation Of MiRNA Transcription	Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Ubiquitin Protein Ligase Binding Embryonic Skeletal System Morphogenesis I-SMAD Binding SMAD Binding Lung Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Skeletal System Morphogenesis Entrainment Of Circadian Clock By Photoperiod Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction Trachea Formation Trophoblast Cell Migration PTW/PP1 Phosphatase Complex Embryonic Organ Morphogenesis Photoperiodism Entrainment Of Circadian Clock Activin Receptor Signaling Pathway Embryonic Foregut Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Cell Fate Commitment Tissue Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Tissue Development Gastrulation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Branching Involved In Lung Morphogenesis Tube Morphogenesis Positive Regulation Of Developmental Process Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription Elongation By RNA Polymerase II Mesenchyme Development Regulation Of Developmental Process Formation Of Primary Germ Layer Branching Morphogenesis Of An Epithelial Tube Osteoblast Differentiation Bronchus Development Animal Organ Formation Positive Regulation Of DNA-templated Transcription, Elongation Catenin-TCF7L2 Complex Paraxial Mesoderm Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex Regulation Of Translation In Response To Stress Circadian Regulation Of Gene Expression In Utero Embryonic Development Regulation Of SMAD Protein Signal Transduction Developmental Growth
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