PRRG4 and HLA-C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRRG4	HLA-C
Gene Name		proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)	major histocompatibility complex, class I, C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Integral Component Of Membrane	Golgi Membrane Extracellular Region Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Molecular_function Calcium Ion Binding	Receptor Binding Peptide Antigen Binding TAP Binding
	Biological Process	Biological_process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways			Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629)	AIDS progression ( 19115949) Atopic dermatitis ( 23042114) Beta-2 microglubulin plasma levels ( 23417110) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233) Height ( 23563607) HIV-1 control ( 21051598 20041166) Hypothyroidism ( 22493691) Nasopharyngeal carcinoma ( 20512145) Protein quantitative trait loci ( 18464913) Psoriasis ( 20953188 20953190 18369459 18364390 19169254) Psoriatic arthritis ( 20953186) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		7 interactors: AOC3 BCL10 HDAC1 HLA-C RBBP8 UBE2K VEGFA	20 interactors: B2M BATF2 CALR CD8A CDC25A CXCR4 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 PRRG4 TANK TAP2 TAPBP YBX1
Entrez ID		79056	3107
HPRD ID		15187	00829
Ensembl ID		ENSG00000135378	ENSG00000204525
Uniprot IDs		Q9BZD6	O19617 P10321 Q6R739 Q95HC2
PDB IDs			3BZF
Enriched GO Terms of Interacting Partners?		Response To Stress Embryo Development Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Tube Formation Negative Regulation Of Transcription From RNA Polymerase II Promoter Chordate Embryonic Development Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Positive Regulation Of Mast Cell Chemotaxis Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Histone Deacetylase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process Interleukin-6 Production Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cardiac Vascular Smooth Muscle Cell Differentiation Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Cardiac Muscle Fiber Development Programmed Cell Death	Immune System Process Regulation Of Immune System Process Regulation Of Immune Response Immune Response Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Immune Response-inhibiting Signal Transduction Defense Response Response To Biotic Stimulus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Response To Stress Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Fc Receptor Mediated Inhibitory Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Cell Activation Response To Other Organism Regulation Of Dendritic Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Response To Stimulus Leukocyte Activation Antigen Processing And Presentation Of Endogenous Antigen Single Organismal Cell-cell Adhesion Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Innate Immune Response Response To External Stimulus Immune Response-regulating Signaling Pathway Dendritic Cell Differentiation Negative Regulation Of Calcium Ion Transport Peptide Antigen Assembly With MHC Class I Protein Complex Cytotoxic T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Interferon-beta Secretion Peptide Antigen Stabilization Negative Regulation Of Transforming Growth Factor-beta Secretion Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Gamma-delta T Cell Activation Involved In Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Signal Transduction
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