SETX and SUMO2

Number of citations of the paper that reports this interaction (PMID 16524884)
113

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)

		SETX	SUMO2
Gene Name		senataxin	small ubiquitin-like modifier 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Axon Growth Cone	Nucleus Nucleoplasm PML Body
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding	Protein Binding Ubiquitin Protein Ligase Binding Poly(A) RNA Binding
	Biological Process	MAPK Cascade Double-strand Break Repair Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection RNA Processing Cellular Response To DNA Damage Stimulus Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development DNA Duplex Unwinding Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Termination Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways			SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BRCA1 SUMO1 SUMO2 UBE2I	91 interactors: ALAS1 ARL13A ARNTL ATXN1 ATXN7 AURKB BAD BCL11A BLM BRCC3 BRE C18orf25 CCNE2 CDCA8 CENPC CHAF1A CHD3 CMTM6 CORO2A CSNK2B CUL3 FAM175A FOS HDAC4 HDAC9 HIF1A HIPK2 HNF4A HOMEZ HSF2 JUN KALRN KDM1A KRT14 KRT5 KRT8 LEF1 MAF1 MAST2 MDC1 MSX1 MYB NFKBIA PARP1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAC1 RANGAP1 RB1 RNF111 RNF4 SAE1 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SETDB1 SETX SH3KBP1 SLC22A2 SNCA SOX10 SOX6 SP100 STK24 SUMO1 TDG TDP2 TEAD3 TNIP1 TOPORS TP53BP2 TRIM63 UBA2 UBE2I USP25 USPL1 VIM WRN XPC ZBTB1 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM5
Entrez ID		23064	6613
HPRD ID		07622	04332
Ensembl ID		ENSG00000107290	ENSG00000188612
Uniprot IDs		Q7Z333	P61956
PDB IDs			1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2RPQ 3UIN 3UIO
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Peptidyl-lysine Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Histone H3-K9 Acetylation Cellular Protein Modification Process Negative Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Chromosome Segregation PML Body Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Response To Indole-3-methanol Positive Regulation Of Proteolysis Negative Regulation Of Centriole Replication Protein Localization To Nuclear Pore Dosage Compensation By Inactivation Of X Chromosome Protein Localization To Nuclear Envelope Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Cellular Protein Metabolic Process	Protein Sumoylation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Peptidyl-lysine Modification Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Binding RNA Metabolic Process Cellular Metabolic Process Gene Expression Chromosome Organization Organelle Organization Regulation Of DNA Binding Biosynthetic Process Response To Stimulus Regulation Of Cellular Process Cellular Response To Stimulus Negative Regulation Of Binding Protein Modification By Small Protein Conjugation Peptidyl-amino Acid Modification Regulation Of Cell Differentiation Regulation Of Signal Transduction Cellular Response To Stress
Tagcloud ?		als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Difference) ?		als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp	augment consequent delaying elusive emerged enhance enhancing facilitates fasting fate linking maintenance melanoma modifications modified node nutrient partner promising relief rev1 sensing short specialized starvation suppressor therapies toxic turn
Tagcloud (Intersection) ?