SETX and BCYRN1

Number of citations of the paper that reports this interaction (PubMedID 24244371)
56

Data Source:
BioGRID (two hybrid)

		SETX	BCYRN1
Description		senataxin	brain cytoplasmic RNA 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Nuclear Body Axon Growth Cone Cell Projection Intercellular Bridge
	Molecular Function	Nucleotide Binding Transcription Termination Site Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Identical Protein Binding
	Biological Process	DNA Repair Double-strand Break Repair DNA Recombination DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Splice Site Recognition RNA Processing DNA Damage Response Spermatogenesis Nervous System Development Circadian Rhythm Positive Regulation Of Neuron Projection Development Cell Differentiation Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Termination Of DNA-templated Transcription Cellular Response To Hydrogen Peroxide Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Pathways
Drugs
Diseases		Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Distal hereditary motor neuropathies (dHMN)
GWAS		Current cigarettes per day in chronic obstructive pulmonary disease ( 29631575) Metabolite levels ( 23823483)	Height ( 31562340) Prostate cancer ( 25217961)
Interacting Genes		15 interacting genes: BCYRN1 BRCA1 CHD3 EXOSC9 HIPK2 PIAS1 PTEN RNF10 SUMO1 SUMO2 TDG TOPORS UBA2 UBC UBE2I	1 interacting genes: SETX
Entrez ID		23064	618
HPRD ID		07622
Ensembl ID		ENSG00000107290	ENSG00000236824
Uniprot IDs		Q7Z333
PDB IDs
Enriched GO Terms of Interacting Partners?		PML Body Protein Sumoylation Protein Modification By Small Protein Conjugation SUMO Transferase Activity Small Protein Activating Enzyme Binding Presynaptic Cytosol Post-translational Protein Modification Postsynaptic Cytosol Protein Modification Process Protein Tag Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Ubiquitin Protein Ligase Binding Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Macromolecule Metabolic Process PML Body Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Enzyme Binding RNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis SUMO Binding Nucleus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Damage Response Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Macromolecule Metabolic Process XY Body Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Glutamatergic Synapse Regulation Of Macromolecule Biosynthetic Process	Transcription Termination Site Sequence-specific DNA Binding Termination Of RNA Polymerase II Transcription Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled DNA-templated Transcription Termination Nuclear Chromosome Positive Regulation Of Protein-containing Complex Disassembly MRNA Splice Site Recognition DNA Helicase Activity Positive Regulation Of RNA Splicing Cellular Response To Hydrogen Peroxide Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Intercellular Bridge Response To Hydrogen Peroxide Cellular Response To Reactive Oxygen Species Helicase Activity Regulation Of Protein-containing Complex Disassembly Circadian Rhythm Growth Cone Positive Regulation Of Neuron Projection Development Response To Reactive Oxygen Species Chromosome, Telomeric Region Regulation Of RNA Splicing
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