SETX

Gene Name		senataxin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Axon Growth Cone
	Molecular Function	Transcription Termination Site Sequence-specific DNA Binding DNA Binding DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Double-strand Break Repair Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection RNA Processing Cellular Response To DNA Damage Stimulus Circadian Rhythm Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development DNA Duplex Unwinding Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Termination Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of DNA-templated Transcription, Initiation Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: BRCA1 SUMO1 SUMO2 UBE2I
Entrez ID		23064
HPRD ID		07622
Ensembl ID		ENSG00000107290
Uniprot IDs		Q7Z333
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Protein Modification By Small Protein Conjugation Post-translational Protein Modification Peptidyl-lysine Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Positive Regulation Of SUMO Transferase Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Histone H3-K9 Acetylation Cellular Protein Modification Process Negative Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Chromosome Segregation PML Body Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Response To Indole-3-methanol Positive Regulation Of Proteolysis Negative Regulation Of Centriole Replication Protein Localization To Nuclear Pore Dosage Compensation By Inactivation Of X Chromosome Protein Localization To Nuclear Envelope Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Regulation Of Histone H4 Acetylation Negative Regulation Of Fatty Acid Biosynthetic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		als2 c147r causative chmp2b dao dctn1 diagnose f21c faces fig4 g148d g59r got haloplex optn pedigree pfn1 probands sanger segregate sigmar1 sod1 spg11 sqstm1 synonymous tardbp ubqln2 vapb vcp