RORC and EIF4EBP1

Number of citations of the paper that reports this interaction (PMID 10405182)
10

Data Source:
HPRD (in vitro)

		RORC	EIF4EBP1
Gene Name		RAR-related orphan receptor C	eukaryotic translation initiation factor 4E binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleoplasm Cytoplasm Cytosol Protein Complex
	Molecular Function	Transcription Coactivator Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Direct Ligand Regulated Sequence-specific DNA Binding Transcription Factor Activity	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Xenobiotic Metabolic Process Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression T Cell Differentiation In Thymus Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Regulation Of Gamma-delta T Cell Differentiation Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Lymph Node Development Peyer's Patch Development Adipose Tissue Development Regulation Of Transcription Involved In Cell Fate Commitment Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Response To Ischemia Translation Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	IRS-mediated signalling mTOR signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Release of eIF4E Eukaryotic Translation Initiation PKB-mediated events Cap-dependent Translation Initiation PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Translation IRS-related events Release of eIF4E mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: CHD4 EIF3I EIF4EBP1 EVI2A NCOA6	32 interactors: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAP1 MAPKAPK5 MLST8 MTOR MVD PPP2CA PPP2R4 PRKCA PRKDC REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4
Entrez ID		6097	1978
HPRD ID		04250	03746
Ensembl ID		ENSG00000143365	ENSG00000187840
Uniprot IDs		B6ZGS6 F1D8P6 H7BYJ4 P51449 Q6I9R9	Q13541
PDB IDs		3B0W 3KYT 3L0J 3L0L	1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Translational Initiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Translation Glucocorticoid Receptor Signaling Pathway Gene Expression Cytoplasmic Translational Initiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cytoplasmic Translation Posttranscriptional Regulation Of Gene Expression Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex TOR Signaling Labyrinthine Layer Blood Vessel Development Response To Ischemia Biosynthetic Process Translation Regulation Of Gene Expression	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Cycle Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Cellular Protein Modification Process Regulation Of Protein Phosphorylation Cell Communication Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Protein Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Cell Death
Tagcloud ?		1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		1q21 3f2 approved chromosomal consists corresponds exon exons finger gamma genomic hgmw introns kb mapped mror orphan p1 polyadenylation rzr spanning splice steroid subfamily superfamily symbol syntenic tr3	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?