RORC and CLOCK

Number of citations: 45 (PubMedID 23555304)
Data Source: BioGRID (two hybrid, affinity chromatography technology)

		RORC	CLOCK
Name		RAR related orphan receptor C	clock circadian regulator
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytoplasm Cytosol Chromatoid Body CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Ligand-modulated Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity Protein-lysine-acetyltransferase Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Circadian Rhythm Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Rhythmic Process Lymph Node Development Peyer's Patch Development Adipose Tissue Development Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation	DNA Damage Checkpoint Signaling Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Acetylation DNA Damage Response Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Regulation Of Gene Expression Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Pathways		Nuclear Receptor transcription pathway Interleukin-4 and Interleukin-13 signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression	BMAL1:CLOCK,NPAS2 activates circadian expression BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression HATs acetylate histones Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 30929738 31619474 ) Asthma (childhood onset) ( 30929738 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Inflammatory bowel disease ( 23128233 28067908 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Ulcerative colitis ( 28067908 )	A body shape index ( 34021172 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 33020668 ) Cortical surface area (MOSTest) ( 32665545 ) Height ( 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Neutrophil percentage of white cells ( 32888494 ) Personality dimensions ( 18957941 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Novel Interactors		None recorded	1 novel interactors: CEP135
Interacting Genes		24 interacting genes: BHLHE41 BMAL2 CHD4 CIPC CLOCK CSNK1E DELEC1 EIF4EBP1 EVI2A FBXL15 NCOA6 NPAS2 NR1D2 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PSMC5 RORB	26 interacting genes: ARNT BHLHE41 BMAL1 BMAL2 CRY1 CRY2 CSNK1E CSNK2B DBP DELEC1 EP300 KAT2B PER2 PER3 PPP1CA PPP1CB PPP1CC PPP2R1B PPP2R5D PPP2R5E RARA RHOA RORB RORC RXRA SIRT1
Entrez ID		6097	9575
HPRD ID		04250	03508
Ensembl ID		ENSG00000143365	ENSG00000134852
Uniprot IDs		B4DPR1 F1D8P6 P51449 Q6I9R9	O15516 Q3ZCT4 Q53EU0
PDB IDs		3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6LO9 6LOA 6LOB 6LOC 6NAD 6NWS 6NWT 6NWU 6O3Z 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6SLZ 6T4G 6T4I 6T4J 6T4K 6T4T 6T4U 6T4W 6T4X 6T4Y 6T50 6TLM 6TLQ 6TLT 6U25 6UCG 6VQF 6VSW 6W9H 6W9I 6XAE 6XFV 7E3M 7JH2 7JTM 7JTW 7JYM 7KCO 7KQJ 7KXD 7KXE 7KXF 7LUK 7NEC 7NP5 7NP6 7NPC 7OFI 7OFK 7QP4 7W3P 7W3Q 7XQE 8FAV 8FB1 8FB2 8GXP 8X7E 8XU5	4H10 6QPJ
GO Terms Enriched among Interactors		Circadian Regulation Of Gene Expression Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Protein Phosphatase Type 2A Complex Photoperiodism Entrainment Of Circadian Clock CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion Nucleus Glycogen Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Polysaccharide Metabolic Process Energy Reserve Metabolic Process Protein Dephosphorylation Chromatin Regulation Of Gene Expression Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sister Chromatid Cohesion Nucleoplasm Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dephosphorylation Phosphoprotein Phosphatase Activity DNA-templated Transcription Elongation Negative Regulation Of RNA Metabolic Process E-box Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Light Stimulus Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromosome, Telomeric Region Chromosome Organization Protein Dimerization Activity Negative Regulation Of Circadian Rhythm	Circadian Regulation Of Gene Expression Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Entrainment Of Circadian Clock Entrainment Of Circadian Clock By Photoperiod Photoperiodism Regulation Of Transcription By RNA Polymerase II Response To Light Stimulus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Chromatin Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Glucose Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Radiation Nuclear Receptor Activity Gluconeogenesis Hexose Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Carbohydrate Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Aryl Hydrocarbon Receptor Complex Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Binding Negative Regulation Of Circadian Rhythm Carbohydrate Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Metabolic Process Peptidyl-lysine Acetylation Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process