CNOT1 and BBS2

Data Source: HiPPIP (Novel)

		CNOT1	BBS2
Name		CCR4-NOT transcription complex subunit 1	Bardet-Biedl syndrome 2
Structure			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Cilium Membrane Motile Cilium Stereocilium Centriolar Satellite BBSome Ciliary Basal Body Cell Projection Neuron Projection Ciliary Membrane
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Nuclear Estrogen Receptor Binding Nuclear Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Translation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Sperm Axoneme Assembly Visual Perception Intracellular Protein Localization Gene Expression Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Protein Transport Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Melanosome Transport Leptin-mediated Signaling Pathway Protein Localization To Organelle Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Response To Leptin Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Non-motile Cilium Assembly
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors	BBSome-mediated cargo-targeting to cilium
Diseases		None	Bardet-Biedl syndrome (BBS)
GWAS		Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) HDL cholesterol levels ( 32203549 ) HDL cholesterol levels in HIV infection ( 33109212 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Platelet count ( 32888494 ) Pork consumption ( 32066663 ) PR interval ( 32439900 ) Pulse pressure ( 30224653 ) QT interval ( 30679814 19305408 29874175 24952745 22726844 ) Schizophrenia ( 30285260 29483656 25056061 ) Serum alkaline phosphatase levels ( 33547301 )	No GWAS studies recorded
Novel Interactors		4 novel interactors: AMFR BBS2 HSF4 NOD2	10 novel interactors: APOC2 CES1 CETP CNOT1 GOT2 HSF4 KCNK17 MAP2K5 SPTSSA WRNIP1
Interacting Genes		13 interacting genes: CDC42 CEBPA CNOT2 CNOT3 CNOT4 CNOT8 DDX6 NANOS3 OBI1 PPARG RARA RXRA THRB	17 interacting genes: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 FNDC3B HNRNPF HSCB KRT18 LMO4 MDFI NRF1 PAX2 PJA2 PSME3 RBPMS UBC
Entrez ID		23019	583
HPRD ID		11999	05855
Ensembl ID		ENSG00000125107	ENSG00000125124
Uniprot IDs		A5YKK6	A0A804HIE1 A0A804HKG1 Q9BXC9
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA 7VOI 8BFI 8FY3 9FL8	Not available
GO Terms Enriched among Interactors		CCR4-NOT Complex Negative Regulation Of Macromolecule Biosynthetic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Biosynthetic Process Retinoic Acid Receptor Signaling Pathway CCR4-NOT Core Complex Negative Regulation Of Macromolecule Metabolic Process P-body MRNA Metabolic Process Negative Regulation Of Metabolic Process MRNA Transcription By RNA Polymerase II Cell Differentiation RNA Polymerase II Transcription Regulator Complex Nuclear Receptor Activity MRNA Transcription Negative Regulation Of Gene Expression Cellular Developmental Process RNA Metabolic Process Regulation Of Translation Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding MRNA Catabolic Process Regulation Of Metabolic Process Positive Regulation Of Lipoprotein Transport Myeloid Leukocyte Differentiation Response To Nutrient Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression LBD Domain Binding Retinoic Acid-responsive Element Binding Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Transcription By RNA Polymerase II Regulatory NcRNA-mediated Gene Silencing Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Macromolecule Catabolic Process Enzyme Binding RNA Catabolic Process Chromatin Nucleic Acid Metabolic Process Protein Autoubiquitination Regulation Of Protein Metabolic Process	Reverse Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Centriolar Satellite Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Regulation Of Cholesterol Transport Regulation Of Primary Metabolic Process Sterol Transport Sterol Homeostasis Cholesterol Homeostasis Microtubule Organizing Center