CNOT1 and THRB

Number of citations of the paper that reports this interaction (PMID 16778766)
20

Data Source:
HPRD (two hybrid)

		CNOT1	THRB
Gene Name		CCR4-NOT transcription complex, subunit 1	thyroid hormone receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Extracellular Space Nucleoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Protein Complex Scaffold Retinoic Acid Receptor Binding Poly(A) RNA Binding Armadillo Repeat Domain Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Multicellular Organismal Development Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		QT interval ( 22726844 19305408)	Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		8 interactors: CNOT2 CNOT3 CNOT4 CNOT8 PPARG RARA RXRA THRB	58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3
Entrez ID		23019	7068
HPRD ID		11999	07521
Ensembl ID		ENSG00000125107	ENSG00000151090
Uniprot IDs		A5YKK6	F1D8N7 P10828
PDB IDs		4GMJ 4GML 4J8S	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing Regulation Of Translation Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway RNA 3'-end Processing Hormone-mediated Signaling Pathway Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Gene Expression RNA Catabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Gene Silencing By RNA Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Gene Silencing Cellular Response To Organic Cyclic Compound Cellular Response To Lipid MRNA Processing Response To Retinoic Acid Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Stem Cell Maintenance Trophectodermal Cell Differentiation RNA Processing Cellular Response To Hormone Stimulus Response To Vitamin A	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone
Tagcloud ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Difference) ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Intersection) ?