CNOT1 and CNOT2

Number of citations of the paper that reports this interaction (PMID 10637334)
50

Data Source:
HPRD (in vivo, two hybrid)

		CNOT1	CNOT2
Gene Name		CCR4-NOT transcription complex, subunit 1	CCR4-NOT transcription complex, subunit 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Extracellular Space Nucleoplasm Peroxisomal Membrane Cytosol Membrane CCR4-NOT Complex	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex
	Molecular Function	Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Protein Complex Scaffold Retinoic Acid Receptor Binding Poly(A) RNA Binding Armadillo Repeat Domain Binding	RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Corepressor Binding Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated Multicellular Organismal Development Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Maintenance	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Translation Gene Expression Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Maintenance
Pathways		Deadenylation of mRNA Deadenylation-dependent mRNA decay	Deadenylation of mRNA Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS		QT interval ( 22726844 19305408)	Amyotrophic lateral sclerosis (age of onset) ( 22959728)
Protein-Protein Interactions		8 interactors: CNOT2 CNOT3 CNOT4 CNOT8 PPARG RARA RXRA THRB	7 interactors: CNOT1 CNOT3 CNOT8 DDB1 GPS2 NCOR1 NCOR2
Entrez ID		23019	4848
HPRD ID		11999	05367
Ensembl ID		ENSG00000125107	ENSG00000111596
Uniprot IDs		A5YKK6	B2RDX7 B3KTL6 Q9NZN8
PDB IDs		4GMJ 4GML 4J8S
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA 3'-end Processing Regulation Of Translation Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway RNA 3'-end Processing Hormone-mediated Signaling Pathway Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process MRNA Catabolic Process Posttranscriptional Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Gene Expression RNA Catabolic Process Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Gene Silencing By RNA Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Gene Silencing Cellular Response To Organic Cyclic Compound Cellular Response To Lipid MRNA Processing Response To Retinoic Acid Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Nitrogen Compound Metabolic Process Response To Steroid Hormone Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Epithelial Cell Differentiation MRNA Metabolic Process Regulation Of Stem Cell Maintenance Trophectodermal Cell Differentiation RNA Processing Cellular Response To Hormone Stimulus Response To Vitamin A	Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Silencing By RNA MRNA 3'-end Processing Gene Silencing RNA 3'-end Processing Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of MRNA Catabolic Process RNA Catabolic Process Regulation Of Stem Cell Maintenance Chromatin Organization RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Negative Regulation Of JNK Cascade Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing By MiRNA Negative Regulation Of Stress-activated MAPK Cascade Regulation Of Translation Cellular Macromolecule Catabolic Process Posttranscriptional Gene Silencing Regulation Of Cellular Protein Metabolic Process Chromosome Organization Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process MRNA Processing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Posttranscriptional Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Phosphodiester Bond Hydrolysis Regulation Of Gene Expression RNA Processing Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway
Tagcloud ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Difference) ?		accelerate cap ccr4 ddx6 deadenylase decapping decay disrupt effector eif4a eif4g exonucleolytic facilitates impair initiated micrornas mirisc mirna mirnas placing repress repressor resembling scaffolding shortening silencing subdomain tail widespread	11q23 12q11 12q14 12q15 12q21 17q11 17q12 3p12 6p21 6q21 6q23 9p13 9p21 acc accs adenoid amplicons ccnd3 cnas glipr1l1 mec mecs mucoepidermoid numa1 pax5 pvrl1 rab3ip sdc statuses
Tagcloud (Intersection) ?